DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and CG1024

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001138014.2	Gene:	CG1024 / 40789	FlyBaseID:	FBgn0027514	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	85/419 - (20%)
Similarity:	119/419 - (28%)	Gaps:	174/419 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VEKHDPLSNTICKSCLEDAQNAFDIIETYERSHQFYRFLKDVREEESE----------------- 74
            |.:..|:|| :.:..|:...||::.|               ||:||.|
  Fly   207 VNEPKPISN-VSELNLDRCLNAYEDI---------------VRKEEKEVVPKYDDELDALCKEFF 255

  Fly    75 NDGSGCSEEVEAAERDLQDGADDVDSGNEPDINECDIKAKEKPGFSCSHCPKSFQVKSNLKVHMR 139
            :||....:. ||.|...||.|.......|..|.|.|...||:              .:.||..|:
  Fly   256 DDGPSAGKG-EANEEQQQDDAHLQQGNQEVVIIEIDALGKEE--------------VAQLKKEMK 305

  Fly   140 SHTGERPF---TCSLCPKSFGYSSGLQNHMRTH--TGERPFQCSHCPRSFTAGHHLKAHIQMHER 199
            |....:|.   ..|..|     |......|.|:  |....:.|..|.:...:....:||
  Fly   306 SDPISQPTKRRRISTTP-----SRDSDTEMSTNGLTKLISYLCPKCGKEIASMDGWRAH------ 359

  Fly   200 RGSLRCPYCQKCFLTSLILKQHLATHTDETQFK---------CSQCS--KSFQVEHELWMHMRVH 253
                             :.|:|...|..|..||         |.||.  :...|..:|..
  Fly   360 -----------------VFKKHDFEHIIENSFKILESGRKAMCLQCREVQPTTVRSQLQK----- 402

  Fly   254 QERLFTCGHCSKDFALHAYLKRHLSRNARCSQSSKASAHKTLGHSKALKCGKCPKTFTDRSALST 318
                    ||.|.....:|                            |||..|.:|.|..|.:..
  Fly   403 --------HCFKHLPYRSY----------------------------LKCTLCDRTKTSTSKILN 431

  Fly   319 HLK-SH-----TKNK--------PLLEGPCKSSGSKPA----HSNAQRKPFKCSSCPRTFSRK-- 363
            |:: :|     .|||        |:...|.||..:..|    ..:.|.:...|..|.|.|..|
  Fly   432 HIRYNHQEELQRKNKTQLLIKPEPMWASPNKSGQAAMADDAGSEDDQGEQAVCEHCDRVFRSKWR 496

  Fly   364 ---------------------SALLTHLQ 371
                                 .|||.||:
  Fly   497 YERHIASCRRSGAGKSVEGTVEALLNHLR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	8/35 (23%)
		COG5048	<119..241	CDD:227381	24/137 (18%)
		C2H2 Zn finger	121..141	CDD:275368	3/19 (16%)
		zf-H2C2_2	133..158	CDD:290200	7/27 (26%)
		C2H2 Zn finger	149..169	CDD:275368	4/19 (21%)
		zf-H2C2_2	162..185	CDD:290200	5/24 (21%)
		C2H2 Zn finger	177..197	CDD:275368	4/19 (21%)
		C2H2 Zn finger	205..225	CDD:275368	2/19 (11%)
		zf-C2H2_8	206..286	CDD:292531	15/90 (17%)
		C2H2 Zn finger	233..253	CDD:275368	5/21 (24%)
		C2H2 Zn finger	260..297	CDD:275368	4/36 (11%)
		C2H2 Zn finger	303..323	CDD:275368	6/20 (30%)
		C2H2 Zn finger	353..373	CDD:275368	10/42 (24%)
CG1024	NP_001138014.2	C2H2 Zn finger	30..51	CDD:275368
		C2H2 Zn finger	73..100	CDD:275368
		C2H2 Zn finger	106..123	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100