DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and Oaz

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	71/302 - (23%)
Similarity:	113/302 - (37%)	Gaps:	68/302 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 IKAKEKPGFSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPF 175
            ||::....:.|..|.|:|.....||.|::||....||.|..|.|.|.:......|.:.||.||.:
  Fly   284 IKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNY 348

  Fly   176 QCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKCSQCSKSF 240
            :|.||..:|:...|||.|::                            ||..:..|:||.|::.:
  Fly   349 KCPHCEAAFSRSDHLKIHMK----------------------------THDIQKPFQCSMCNRGY 385

  Fly   241 QVEHELWMHMRVHQERLF----------------TCGHCSKDFALHAYLKRHLSRNARCSQSS-- 287
            .....|..||:.|::...                :.|..|...:.:..|::.....|..|.||
  Fly   386 NTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPS 450

  Fly   288 -----KASAHKTLGHSKA-------LKCGKCPKT--FTDRSALSTHLKSHTKNKPLLEGPCKSSG 338
                 |.|....:|.:..       |:|..|||.  |:....|:.||:|      :.|.| ::..
  Fly   451 RMDFPKRSRSNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQS------VHEQP-QTQA 508

  Fly   339 SKPAHSNAQRKPFKCSSCPRTFSRKSALLTHLQ-THTGKLGT 379
            .|......:.....|..|...|...:.|..|:: ||..:|.:
  Fly   509 VKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSS 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071
		COG5048	<119..241	CDD:227381	34/121 (28%)
		C2H2 Zn finger	121..141	CDD:275368	7/19 (37%)
		zf-H2C2_2	133..158	CDD:290200	11/24 (46%)
		C2H2 Zn finger	149..169	CDD:275368	5/19 (26%)
		zf-H2C2_2	162..185	CDD:290200	8/22 (36%)
		C2H2 Zn finger	177..197	CDD:275368	8/19 (42%)
		C2H2 Zn finger	205..225	CDD:275368	0/19 (0%)
		zf-C2H2_8	206..286	CDD:292531	15/95 (16%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..297	CDD:275368	9/43 (21%)
		C2H2 Zn finger	303..323	CDD:275368	8/21 (38%)
		C2H2 Zn finger	353..373	CDD:275368	5/20 (25%)
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		C2H2 Zn finger	322..342	CDD:275368	5/19 (26%)
		zf-H2C2_2	334..359	CDD:290200	9/24 (38%)
		COG5048	336..769	CDD:227381	54/250 (22%)
		zf-C2H2	348..370	CDD:278523	8/49 (16%)
		C2H2 Zn finger	350..370	CDD:275368	8/47 (17%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	689..707	CDD:275368
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930