DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and az2

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	85/340 - (25%)
Similarity:	134/340 - (39%)	Gaps:	76/340 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 HDPLSNTIC-----KSCLEDAQNA------------FDIIETYERSHQFY-RFLKDVREEESEND 76
            :||.....|     ||.|.:..:.            :|:.::.:...|:| |.:|.:.:.:...
  Fly   287 YDPAHKHFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVYDSIQSMRQWYSRRIKTLTDVQCVG- 350

  Fly    77 GSGCSEEVEAAERDLQDGADDVDSGNEPDINECD--IKAKE-KPGFSCSHCPKSFQVKSNLKVH- 137
                   :..||:..              |..|:  :..|. :....|..|..||.....|:.|
  Fly   351 -------LSLAEKQY--------------IERCNSFMPTKSFRQKLKCEVCEHSFSTDHALQAHQ 394

  Fly   138 MRSH-TGERP-FTCSLCPKSFGYSSGLQNH-MRTHTGERPFQCSHCPRSFTAGHHLKAHIQMHER 199
            .|.| .|:.. |.|:||..:|.....||.| .|.|. ::.|.|..|.|||..|:.|..|.:.|:.
  Fly   395 FRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCEICSRSFAFGNQLAIHKRTHDE 458

  Fly   200 RGSLR---CPYCQKCFLTSLILKQHL-ATHTDETQFKCSQCSKSFQVEHELWMHMRVHQE-RLFT 259
            :...:   |.:|.|||...:.:..|: |.||....|||..|.|.|..:.:|..|::.|.. |...
  Fly   459 KHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKV 523

  Fly   260 CGHCSKDFA-LHAYLK-RHLSRNARCSQSSKASAHKTLGHSKALKCGKCPKTFTDRSALSTHLKS 322
            |..|.|.|. .:|.:| ||:              ||    .|.|:|..|...|::|.:|..|::
  Fly   524 CEVCQKAFTNANALVKHRHI--------------HK----EKTLQCSLCTTRFSERVSLGVHMR- 569

  Fly   323 HTKNKPLLEGPCKSS 337
              :...:|:....||
  Fly   570 --RTHKILKSSLSSS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	9/50 (18%)
		COG5048	<119..241	CDD:227381	43/129 (33%)
		C2H2 Zn finger	121..141	CDD:275368	7/20 (35%)
		zf-H2C2_2	133..158	CDD:290200	10/27 (37%)
		C2H2 Zn finger	149..169	CDD:275368	8/20 (40%)
		zf-H2C2_2	162..185	CDD:290200	10/23 (43%)
		C2H2 Zn finger	177..197	CDD:275368	8/19 (42%)
		C2H2 Zn finger	205..225	CDD:275368	7/20 (35%)
		zf-C2H2_8	206..286	CDD:292531	26/83 (31%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..297	CDD:275368	10/38 (26%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510
		GT1	276..>341	CDD:304916	10/53 (19%)
		C2H2 Zn finger	377..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..429	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..488	CDD:275368	7/20 (35%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	8/33 (24%)
		C2H2 Zn finger	551..572	CDD:275368	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100