DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neu2 and CG2120

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	91/374 - (24%)
Similarity:	140/374 - (37%)	Gaps:	96/374 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DPLSNTICKSCLEDAQNAFDI-IETYERSHQFYRFLKDV------REEESENDGSGCSEEVEAAE 88
            ||:|.....:..:|....:|: :|..    |.:..|:|:      .|.|..|.||    |.:..|
  Fly     5 DPVSQMANATLADDDLGNYDVCLEDL----QLFAQLEDLSGERLPMEMELLNPGS----EYDLLE 61

  Fly    89 RDLQDGADDVDSGNEPDINECDI-KAKEKP----------GFSCSHCPKSFQVKSNLKVHMRSHT 142
              |.:||  :...|..:....|: |.|..|          ..:|..|.:.|....||::|..:||
  Fly    62 --LVNGA--LQQRNTTEHKPTDMCKPKRTPTTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHT 122

  Fly   143 GERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPY 207
            .|:|..|..|.|.|...:.|:.|..|||.|||.:|..|.:.|...::|..|.::
  Fly   123 DEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRL----------- 176

  Fly   208 CQKCFLTSLILKQHLATHTDETQFKC--SQCSKSFQVEHELWMHMRVHQERLFTCGHCSKDFALH 270
                             ||.|..:.|  :.|..||...|...:|.::
  Fly   177 -----------------HTGEKPYPCLATDCHLSFHSIHARRIHTKL------------------ 206

  Fly   271 AYLKRHLSRNARCSQSSKASAHKTLGHSKALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPCK 335
                ||.::.....:...|...:....:.:..|..|.:..||:..||.|||.|...:   :.||.
  Fly   207 ----RHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQR---DFPCP 264

  Fly   336 S--------SGSKPAH---SNAQRKPFKCSSCPRTFSRKSALLTHLQTH 373
            .        |.|:..|   ::.|::||.|..||..|.|||....||:.|
  Fly   265 QPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	7/32 (22%)
		COG5048	<119..241	CDD:227381	33/123 (27%)
		C2H2 Zn finger	121..141	CDD:275368	6/19 (32%)
		zf-H2C2_2	133..158	CDD:290200	11/24 (46%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	162..185	CDD:290200	10/22 (45%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		C2H2 Zn finger	205..225	CDD:275368	0/19 (0%)
		zf-C2H2_8	206..286	CDD:292531	11/81 (14%)
		C2H2 Zn finger	233..253	CDD:275368	6/21 (29%)
		C2H2 Zn finger	260..297	CDD:275368	3/36 (8%)
		C2H2 Zn finger	303..323	CDD:275368	9/19 (47%)
		C2H2 Zn finger	353..373	CDD:275368	9/19 (47%)
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	11/24 (46%)
		C2H2 Zn finger	129..149	CDD:275368	6/19 (32%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	31/165 (19%)
		C2H2 Zn finger	157..177	CDD:275368	5/47 (11%)
		C2H2 Zn finger	185..206	CDD:275368	6/20 (30%)
		C2H2 Zn finger	235..255	CDD:275368	9/19 (47%)
		C2H2 Zn finger	263..285	CDD:275368	4/21 (19%)
		C2H2 Zn finger	293..313	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940