DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and Zfp7

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001345745.1	Gene:	Zfp7 / 223669	MGIID:	99208	Length:	685	Species:	Mus musculus

Alignment Length:	416	Identity:	116/416 - (27%)
Similarity:	162/416 - (38%)	Gaps:	103/416 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EKHDPLSNTI--------------CKSC-----LEDAQNAFDIIETYERSHQFYRFLKDVREEES 73
            ::.|.||:.:              |:.|     .....|...:..|.|:|:|..:
Mouse   170 DQRDHLSSKLIRRQSVPTGENRYPCEECGKAFRWRSRLNQHKLSHTGEKSYQCNK---------- 224

  Fly    74 ENDGSGCSEEVEAAERDLQDGADDVDSGNEPDINECD-----------------IKAKEKPGFSC 121
                  |::...::.|.::.  ....:|.:|  .:||                 |...|:| |.|
Mouse   225 ------CTKVFASSSRLIRH--QRAHTGEKP--FKCDQCGKRFVLASVLTQHQRIHTGERP-FKC 278

  Fly   122 SHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTA 186
            :.|.|.|.:.:.|..|.|.||||:|:.|..|.|:||.||.|.:|.|.|||||||.|..|.::|..
Mouse   279 AECGKGFHLSAKLVQHQRIHTGEKPYRCEECGKTFGQSSSLVHHQRIHTGERPFICQECGKAFCQ 343

  Fly   187 GHHLKAHIQMHERRGSLRCPYCQKCFLTSLILKQH------------------------LATHTD 227
            ...|..|.:.|.......|..|.|.|.....|.||                        ....|:
Mouse   344 RSQLSRHRRTHTGERPYSCQECGKAFCQRATLAQHQKMMHTAEKSQMPRASESPSLIACQGNTTE 408

  Fly   228 ETQFKCSQCSKSFQVEHELWMHMRVHQ-ERLFTCGHCSKDFALHAYLKRHLSRNARCSQSSKASA 291
            |..|||.||.|:|:....|..|..||. |:.:.|..|||.|...:.|.||
Mouse   409 EKPFKCEQCGKAFRWLSRLNQHQVVHSGEKPYQCNKCSKAFGCTSRLIRH--------------- 458

  Fly   292 HKTLGHSKALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPC----KSSGSKPAHSNAQR--KP 350
            .:|....|..||.:|.|.|...|.|..|.:.||..||.:...|    ..|.|...|....:  ||
Mouse   459 QRTHTGEKPFKCDECGKRFVQSSHLIQHQRIHTGEKPYVCDDCGRAFTQSSSLIYHQRIHKGEKP 523

  Fly   351 FKCSSCPRTFSRKSALLTHLQTHTGK 376
            :|||.|.:.||..:.|.:|.:||||:
Mouse   524 YKCSQCGKAFSMSTQLTSHQRTHTGE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	10/53 (19%)
		COG5048	<119..241	CDD:227381	51/145 (35%)
		C2H2 Zn finger	121..141	CDD:275368	7/19 (37%)
		zf-H2C2_2	133..158	CDD:290200	12/24 (50%)
		C2H2 Zn finger	149..169	CDD:275368	10/19 (53%)
		zf-H2C2_2	162..185	CDD:290200	12/22 (55%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		C2H2 Zn finger	205..225	CDD:275368	7/43 (16%)
		zf-C2H2_8	206..286	CDD:292531	28/104 (27%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..297	CDD:275368	9/36 (25%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
Zfp7	NP_001345745.1	KRAB	4..65	CDD:214630
		C2H2 Zn finger	194..214	CDD:275368	3/19 (16%)
		C2H2 Zn finger	222..242	CDD:275368	2/37 (5%)
		COG5048	246..668	CDD:227381	103/322 (32%)
		C2H2 Zn finger	250..270	CDD:275368	2/19 (11%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	10/19 (53%)
		C2H2 Zn finger	334..354	CDD:275368	5/19 (26%)
		C2H2 Zn finger	362..380	CDD:275368	7/17 (41%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		C2H2 Zn finger	442..462	CDD:275368	8/34 (24%)
		C2H2 Zn finger	470..490	CDD:275368	7/19 (37%)
		C2H2 Zn finger	498..518	CDD:275368	4/19 (21%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		C2H2 Zn finger	554..574	CDD:275368
		C2H2 Zn finger	582..602	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3991
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950