DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and si:dkeyp-35e5.10

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_017211229.1	Gene:	si:dkeyp-35e5.10 / 108179204	ZFINID:	ZDB-GENE-110913-63	Length:	331	Species:	Danio rerio

Alignment Length:	352	Identity:	106/352 - (30%)
Similarity:	150/352 - (42%)	Gaps:	67/352 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FLKDVREEESENDGSGCSEEVEAAERDLQDGAD------DVDSGNEPDINECDIKAKEKP----- 117
            |:|    ||||:  ....|.....:.|||:..|      :....|:.:....:|.|.|||
Zfish     3 FIK----EESED--VKIEETFTVKQEDLQEQTDLMVLKEETQQWNKMEEQHQEITADEKPTLTEK 61

  Fly   118 --------------GFSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRT 168
                          .||...|.|||..|.||.||||.|..|:|:||..|.||||.....:.|||.
Zfish    62 TSSLGRSRKSKTECNFSSKQCRKSFSQKPNLGVHMRVHIREKPYTCDQCGKSFGKKKSFKTHMRI 126

  Fly   169 HTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKC 233
            ||||||:.|..|.:||....:...|.::|.......|..|.|.|..|..||.|:.||....:|.|
Zfish   127 HTGERPYTCQECGKSFCQAENFAVHKRIHTGERPYTCQQCGKSFTQSGNLKDHIRTHNGGKKFTC 191

  Fly   234 SQCSKSFQVEHELWMHMRVHQ-ERLFTCGHCSKDFALHAYLKRHL-----SRNARCSQSSKASAH 292
            :||.|||..:.:|..||.:|. |:.:....|.|.|...:.|..|:     .:...|:|..|:...
Zfish   192 TQCGKSFAQKQKLDTHMMIHTGEKPYRFTECGKSFTCKSALNNHMISHTGEKPFACAQCGKSFTT 256

  Fly   293 KTL------GHSKALK--CGKCPKTFTDRSALSTHLKSHTKNKPLLEGPCKSSGSKPAHSNAQRK 349
            ||.      |||..:.  |.:|.|:.|.:..:..|:|:|::                      ..
Zfish   257 KTSLMNHMDGHSGIIVFICDQCGKSLTRKDYIKQHMKTHSR----------------------ED 299

  Fly   350 PFKCSSCPRTFSRKSALLTHLQTHTGK 376
            .|:||.|.:.|.:|..|..|::.|..:
Zfish   300 RFRCSECGKGFKQKINLSAHMKLHNAE 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071
		COG5048	<119..241	CDD:227381	54/121 (45%)
		C2H2 Zn finger	121..141	CDD:275368	11/19 (58%)
		zf-H2C2_2	133..158	CDD:290200	15/24 (63%)
		C2H2 Zn finger	149..169	CDD:275368	9/19 (47%)
		zf-H2C2_2	162..185	CDD:290200	12/22 (55%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-C2H2_8	206..286	CDD:292531	27/85 (32%)
		C2H2 Zn finger	233..253	CDD:275368	9/19 (47%)
		C2H2 Zn finger	260..297	CDD:275368	10/47 (21%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
si:dkeyp-35e5.10	XP_017211229.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000