DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neu2 and si:ch73-158p21.2

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_003198608.1	Gene:	si:ch73-158p21.2 / 100535934	ZFINID:	ZDB-GENE-161017-23	Length:	418	Species:	Danio rerio

Alignment Length:	379	Identity:	123/379 - (32%)
Similarity:	172/379 - (45%)	Gaps:	57/379 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 EDAQNAFDIIETYERSHQFYRFLKDVREEE---SEND----------GSGCSEEVEAAERDLQDG 94
            ||.:...|:....|...:    |.||:|||   ::|.          |.|.:|     :|:|...
Zfish    22 EDHEEQTDLTLLKEEIQE----LNDVKEEEDPKAQNTPQKHFKRHYCGRGFTE-----KRNLTVH 77

  Fly    95 ADDVDSGNE--------PDINECDIKAKEKP---GFSCSHCPKSFQVKSNLKVHMRSHTGERPFT 148
            : .|.:|..        ...|:.|:..|.|.   ...|.||.:.|..| .:|.|||.|||||||.
Zfish    78 S-RVHTGETRFSCKKCGESFNKKDLFEKHKEIHLAVICRHCGRQFTQK-YIKTHMRIHTGERPFR 140

  Fly   149 CSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFL 213
            |..|.|||...|.|..|:.|||||||:.||||...||....|..|:::|.......|..|.|.|.
Zfish   141 CGQCGKSFAQRSTLDTHVITHTGERPYACSHCGNGFTTKASLDCHMRIHTGEKPFTCEQCGKSFS 205

  Fly   214 TSLILKQHLATHTDETQFKCSQCSKSFQVEHELWMHMRVHQ-ERLFTCGHCSKDFALHAYLKRHL 277
            ....|..|:..||.|..|.|.||.|.|.::..|..||.||. |:.::|..|.|.|...|.:..|:
Zfish   206 EKGSLTIHMRFHTGERPFVCYQCGKGFVIKGNLDRHMIVHSGEKPYSCPQCGKGFKHKARIGVHM 270

  Fly   278 -----SRNARCSQSSKA-------SAHKTLGHSK--ALKCGKCPKTFTDRSALSTHLKSHTKNKP 328
                 .:...|.|..|:       .:||.: |.|  .:||.:|..:|.|.|.|..|:::|...||
Zfish   271 MIHSGEKPFACDQCGKSFSTKVHLESHKRV-HLKDNRVKCHQCGMSFPDGSQLKDHVQTHIGQKP 334

  Fly   329 LLEGPC-KSSGSKPA-----HSNAQRKPFKCSSCPRTFSRKSALLTHLQTHTGK 376
            .:...| :|...||:     .|:|..|||.|..|.:::..:..|..|::.|||:
Zfish   335 FMCPECGRSCSKKPSLKIHMRSHAAEKPFTCKQCGKSYCVRGVLNVHMRIHTGE 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	4/19 (21%)
		COG5048	<119..241	CDD:227381	54/121 (45%)
		C2H2 Zn finger	121..141	CDD:275368	9/19 (47%)
		zf-H2C2_2	133..158	CDD:290200	16/24 (67%)
		C2H2 Zn finger	149..169	CDD:275368	8/19 (42%)
		zf-H2C2_2	162..185	CDD:290200	13/22 (59%)
		C2H2 Zn finger	177..197	CDD:275368	8/19 (42%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		zf-C2H2_8	206..286	CDD:292531	27/85 (32%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		C2H2 Zn finger	260..297	CDD:275368	11/48 (23%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	4/19 (21%)
si:ch73-158p21.2	XP_003198608.1	C2H2 Zn finger	62..81	CDD:275368	5/24 (21%)
		COG5048	<69..290	CDD:227381	79/227 (35%)
		C2H2 Zn finger	114..133	CDD:275368	9/19 (47%)
		zf-H2C2_2	127..150	CDD:290200	16/22 (73%)
		C2H2 Zn finger	141..161	CDD:275368	8/19 (42%)
		C2H2 Zn finger	169..189	CDD:275368	8/19 (42%)
		zf-H2C2_2	181..205	CDD:290200	6/23 (26%)
		COG5048	<193..371	CDD:227381	56/178 (31%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		zf-H2C2_2	209..233	CDD:290200	10/23 (43%)
		C2H2 Zn finger	225..245	CDD:275368	8/19 (42%)
		zf-H2C2_2	237..262	CDD:290200	10/24 (42%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	5/20 (25%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	4/19 (21%)
		C2H2 Zn finger	365..385	CDD:275368	4/19 (21%)
		zf-H2C2_2	378..402	CDD:290200	5/11 (45%)
		C2H2 Zn finger	393..413	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000003
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000