DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and znf142

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_002934000.3	Gene:	znf142 / 100485110	XenbaseID:	XB-GENE-1032931	Length:	1898	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	88/374 - (23%)
Similarity:	133/374 - (35%)	Gaps:	116/374 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 KEKPGFSCSHCPKSFQVKSNLKVHMRS-HTGERPFTCSLCPKSFGYSSGLQNH-MRTHTGERPFQ 176
            ::||...||.|..|...::::..||.| |.||..|.|.:|..||...:.|:.| :|.|..:...:
Frog  1480 EKKPTHFCSLCDYSGYSQNDIARHMGSCHNGEPAFPCDVCQASFSSEAALKQHSLRKHQEKATHE 1544

  Fly   177 CSHCP---------RSFTAGHHL---------------------KAHIQMH-------------- 197
            |..|.         |.....|||                     |:|...|
Frog  1545 CLQCQFSCHSLATLRCHLQKHHLQLDCTICKQTFCRRQDLEEHRKSHFAHHCHLCQYAAKDRQQL 1609

  Fly   198 -----------------ERRGSLRCPYCQ----------------------KCFLTSLILKQ--- 220
                             :..|.|.||:|.                      ||.......|.
Frog  1610 VHHYAEEHETPAVPGAEQEMGLLCCPFCSFSCRHQLVYDHHVKGHGGIRVYKCSDCEYTTKNKQK 1674

  Fly   221 ---HLATHTDETQFKCSQCSKSFQVEHELWMHMRVHQ-ERLFTCGHCSKDFALHAYLKRHLSRNA 281
               |...||.|..:||..||.:......|..|||:|: |:.:.|..|.........||.|::::.
Frog  1675 ITWHSRIHTGEKPYKCHLCSYACADPSRLKYHMRIHKDEKKYLCPECGYKCKWVNQLKYHMTKHT 1739

  Fly   282 -----RCSQ----SSKASA---HKTLGHS--KALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEG 332
                 :|.:    :::|.|   |:...|.  ::..|.:|.|.|..|..|.||::.|::.||.:..
Frog  1740 GLKPYQCEECDYCTNRADALRVHRETRHREVRSFICEQCGKAFKTRFLLKTHMRKHSEEKPYVCN 1804

  Fly   333 PCKSSGSKPA--------HSNAQRKPFKCSSCPRTFSRKSALLTHLQTH 373
            .|:.|...||        |:|  :.||.|..|.....:|..::.|||.|
Frog  1805 LCQRSFRWPAGLRHHYLTHTN--QHPFFCQYCTYRAKQKFQVVKHLQRH 1851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071
		COG5048	<119..241	CDD:227381	44/212 (21%)
		C2H2 Zn finger	121..141	CDD:275368	7/20 (35%)
		zf-H2C2_2	133..158	CDD:290200	11/25 (44%)
		C2H2 Zn finger	149..169	CDD:275368	7/20 (35%)
		zf-H2C2_2	162..185	CDD:290200	7/32 (22%)
		C2H2 Zn finger	177..197	CDD:275368	8/49 (16%)
		C2H2 Zn finger	205..225	CDD:275368	7/47 (15%)
		zf-C2H2_8	206..286	CDD:292531	25/117 (21%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..297	CDD:275368	9/48 (19%)
		C2H2 Zn finger	303..323	CDD:275368	8/19 (42%)
		C2H2 Zn finger	353..373	CDD:275368	6/19 (32%)
znf142	XP_002934000.3	C2H2 Zn finger	358..378	CDD:275368
		C2H2 Zn finger	386..406	CDD:275368
		C2H2 Zn finger	414..431	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
		C2H2 Zn finger	534..555	CDD:275368
		C2H2 Zn finger	563..584	CDD:275368
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..640	CDD:275368
		C2H2 Zn finger	648..668	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	703..720	CDD:275368
		C2H2 Zn finger	1401..1422	CDD:275368
		C2H2 Zn finger	1430..1450	CDD:275368
		C2H2 Zn finger	1458..1476	CDD:275368
		C2H2 Zn finger	1516..1537	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1545..1565	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1571..1591	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1634..1654	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1662..1682	CDD:275368	3/19 (16%)
		SFP1	<1684..1739	CDD:227516	16/54 (30%)
		C2H2 Zn finger	1690..1710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1718..1738	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1746..1767	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1775..1795	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1803..1823	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1831..1851	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010