DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and si:ch211-162i8.2

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_021331195.1	Gene:	si:ch211-162i8.2 / 100333435	ZFINID:	ZDB-GENE-110913-56	Length:	1662	Species:	Danio rerio

Alignment Length:	348	Identity:	124/348 - (35%)
Similarity:	173/348 - (49%)	Gaps:	42/348 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FLKDVREEESENDGSGCSEEVEAAERDLQDGADDVDSGNEPDINECDIKAKEKPG---------- 118
            |:|    ||||:  ....|.......|||:..|.::...|....|..:|.:||..
Zfish     3 FIK----EESED--VKIEETFRVKHEDLQEQTDLIEENEESKEEEHHVKIEEKTHLQTDGILKRR 61

  Fly   119 ----FSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSH 179
                .:|:.|.|||...|:|..|||.||||:||||:.|.|||.:||.|..|||.||||:||.|:.
Zfish    62 DKNCLTCTQCGKSFSQSSSLNQHMRIHTGEKPFTCTQCGKSFSHSSSLNLHMRIHTGEKPFTCTQ 126

  Fly   180 CPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKCSQCSKSFQVEH 244
            |.:||:....|..|:::|.......|..|.|||..|..|.||:..||.|..|.|:.|.|||.:..
Zfish   127 CGKSFSHSSSLNLHMRIHTGEKPFTCTQCGKCFSQSSNLNQHMRIHTKEKPFTCTYCGKSFSLSS 191

  Fly   245 ELWMHMRVHQ-ERLFTCGHCSKDFALHAYLKRHLSRN--------ARC----SQSSKASAHKTLG 296
            .|.:|||:|. |:.|.|..|.|.|:..::|..|...:        ::|    ||||..:.|..:
Zfish   192 SLNIHMRIHTGEKPFACTQCGKSFSCLSHLNHHKWIHTGEKPFTCSQCGKSFSQSSSLNIHMRI- 255

  Fly   297 HS--KALKCGKCPKTFTDRSALSTHLKSHTKNKPLL------EGPCKSSGSKPAHSNAQRKPFKC 353
            |:  |...|.:|.|:|:..|:|:.|::.||..||..      ...|.|..:|....:...|||.|
Zfish   256 HTGEKPFTCTQCGKSFSQSSSLNIHMRIHTGEKPFTCTQCGKSFNCSSLLNKHMKIHTGEKPFAC 320

  Fly   354 SSCPRTFSRKSALLTHLQTHTGK 376
            :.|.|:||..|:|..|:..|||:
Zfish   321 TQCGRSFSHSSSLNRHMMRHTGE 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071
		COG5048	<119..241	CDD:227381	58/121 (48%)
		C2H2 Zn finger	121..141	CDD:275368	10/19 (53%)
		zf-H2C2_2	133..158	CDD:290200	16/24 (67%)
		C2H2 Zn finger	149..169	CDD:275368	11/19 (58%)
		zf-H2C2_2	162..185	CDD:290200	13/22 (59%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		C2H2 Zn finger	205..225	CDD:275368	9/19 (47%)
		zf-C2H2_8	206..286	CDD:292531	32/92 (35%)
		C2H2 Zn finger	233..253	CDD:275368	9/19 (47%)
		C2H2 Zn finger	260..297	CDD:275368	12/48 (25%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
si:ch211-162i8.2	XP_021331195.1	COG5048	62..471	CDD:227381	108/283 (38%)
		C2H2 Zn finger	68..88	CDD:275368	10/19 (53%)
		C2H2 Zn finger	96..116	CDD:275368	11/19 (58%)
		C2H2 Zn finger	124..144	CDD:275368	6/19 (32%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		C2H2 Zn finger	180..200	CDD:275368	9/19 (47%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		C2H2 Zn finger	236..256	CDD:275368	6/20 (30%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		C2H2 Zn finger	292..312	CDD:275368	3/19 (16%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		C2H2 Zn finger	349..368	CDD:275368
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	404..424	CDD:275368
		COG5048	428..840	CDD:227381
		C2H2 Zn finger	432..452	CDD:275368
		C2H2 Zn finger	460..480	CDD:275368
		C2H2 Zn finger	488..508	CDD:275368
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	544..564	CDD:275368
		C2H2 Zn finger	572..592	CDD:275368
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	658..678	CDD:275368
		C2H2 Zn finger	686..706	CDD:275368
		C2H2 Zn finger	714..734	CDD:275368
		COG5048	737..1152	CDD:227381
		C2H2 Zn finger	742..762	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368
		C2H2 Zn finger	854..874	CDD:275368
		C2H2 Zn finger	882..902	CDD:275368
		C2H2 Zn finger	910..930	CDD:275368
		C2H2 Zn finger	938..958	CDD:275368
		C2H2 Zn finger	966..986	CDD:275368
		COG5048	990..1374	CDD:227381
		C2H2 Zn finger	994..1014	CDD:275368
		C2H2 Zn finger	1022..1042	CDD:275368
		C2H2 Zn finger	1050..1070	CDD:275368
		C2H2 Zn finger	1078..1098	CDD:275368
		C2H2 Zn finger	1106..1126	CDD:275368
		C2H2 Zn finger	1134..1154	CDD:275368
		C2H2 Zn finger	1162..1182	CDD:275368
		C2H2 Zn finger	1190..1210	CDD:275368
		COG5048	1214..1641	CDD:227381
		C2H2 Zn finger	1218..1238	CDD:275368
		C2H2 Zn finger	1246..1266	CDD:275368
		C2H2 Zn finger	1274..1294	CDD:275368
		C2H2 Zn finger	1302..1322	CDD:275368
		C2H2 Zn finger	1330..1350	CDD:275368
		C2H2 Zn finger	1358..1378	CDD:275368
		C2H2 Zn finger	1386..1406	CDD:275368
		C2H2 Zn finger	1414..1434	CDD:275368
		C2H2 Zn finger	1442..1462	CDD:275368
		C2H2 Zn finger	1470..1490	CDD:275368
		C2H2 Zn finger	1498..1518	CDD:275368
		C2H2 Zn finger	1550..1570	CDD:275368
		C2H2 Zn finger	1578..1595	CDD:275368
		C2H2 Zn finger	1606..1626	CDD:275368
		C2H2 Zn finger	1634..1654	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000