DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neu2 and LOC100329723

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_017210872.1	Gene:	LOC100329723 / 100329723	-ID:	-	Length:	383	Species:	Danio rerio

Alignment Length:	388	Identity:	112/388 - (28%)
Similarity:	179/388 - (46%)	Gaps:	76/388 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASVFDESHEPGLSIAYIIYKCTGWQVEKHDPLSNTICKSCLEDAQNAFDIIETYERSHQFYRFL 65
            ||.:.:||.:..:...:|:.:                     ||.|...|::...|.:||:.: :
Zfish     1 MAFIKEESEDVEIEETFIVKQ---------------------EDLQEQTDLMVLKEETHQWNK-M 43

  Fly    66 KDVREEESENDGSGCSEEVEAAERDLQDGADDVDSGNEPDINECDIKAKEKPGFSCSHCPKSFQV 130
            ::..:|.:.::....:|:..:..|..:..            .||::.:|:        |.|||..
Zfish    44 EEQHQEITADEKPTLTEKTSSLGRPRKSK------------TECNLSSKQ--------CRKSFIQ 88

  Fly   131 KSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAHIQ 195
            |.||..|||.||.|:|:||..|.||||....|:.|||.||||||:.|..|.:||.....||.|::
Zfish    89 KLNLGDHMRVHTREKPYTCEQCGKSFGKKRSLKTHMRIHTGERPYTCQQCGKSFKQIGTLKGHMR 153

  Fly   196 MHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKCSQCSKSFQVEHELWMHMRVHQ-ERLFT 259
            :|.......|..|.|.|..|..||.|:.:||.|..:.|.||.:||........|.|:|. |:.:|
Zfish   154 IHTGERPYTCQQCGKSFKQSATLKGHMRSHTGERPYTCQQCGQSFYYAGNFAAHKRIHTGEKPYT 218

  Fly   260 CGHCSKDF----ALHAYLKRHLSRNARC----SQSSKASAHKTLGHS--KALKCGKCPKTFTDRS 314
            |..|.|.|    .|.::::.|.....:|    :|..|...|.|: |:  |..:|.:|.|:||.:|
Zfish   219 CQQCGKSFKQSGTLKSHMRIHNGGKTQCGKSFAQKQKFDTHMTI-HTEEKPYRCTECGKSFTCKS 282

  Fly   315 ALSTHLKSHTKNKPLLEGPCKSSGSKPAHSNAQRKPFKCSSCPRTFSRKSALLTHLQTHTGKL 377
            :|..|:|:||:                      .|.|.|:.|.::|:.|:.|:.|:..|:|.:
Zfish   283 SLINHMKTHTR----------------------EKLFTCNQCEKSFTCKANLMNHMDGHSGNI 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	12/61 (20%)
		COG5048	<119..241	CDD:227381	54/121 (45%)
		C2H2 Zn finger	121..141	CDD:275368	10/19 (53%)
		zf-H2C2_2	133..158	CDD:290200	15/24 (63%)
		C2H2 Zn finger	149..169	CDD:275368	10/19 (53%)
		zf-H2C2_2	162..185	CDD:290200	13/22 (59%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-C2H2_8	206..286	CDD:292531	27/88 (31%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..297	CDD:275368	11/44 (25%)
		C2H2 Zn finger	303..323	CDD:275368	9/19 (47%)
		C2H2 Zn finger	353..373	CDD:275368	6/19 (32%)
LOC100329723	XP_017210872.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000