DRSC/TRiP Functional Genomics Resources

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Protein Alignment croc and Foxo1

DIOPT Version :10

Sequence 1:NP_524202.1 Gene:croc / 40374 FlyBaseID:FBgn0014143 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_001178775.1 Gene:Foxo1 / 84482 RGDID:620283 Length:649 Species:Rattus norvegicus


Alignment Length:525 Identity:107/525 - (20%)
Similarity:191/525 - (36%) Gaps:176/525 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FSDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYA-------YDQYSRYP-------YSAS 55
            |:..||.|...|.:.:...:..|.|:.:||||.:....:       .:.::|.|       .:|:
  Rat    32 FNQSNSTTSSPAPSGSTAANPDATASLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAA 96

  Fly    56 AYGLGAPHQNKE----------------IVKPP---------------------------YSYIA 77
            :.||....|..|                :.:||                           .||..
  Rat    97 SRGLCGDFQGPEAGCVHSAPPQPPPTGPLSQPPPVPPAAAGPLAGQPRKTSSSRRNAWGNLSYAD 161

  Fly    78 LIAMAIQNAADKKVTLNGIYQYIMERFPYYRD-----NKQGWQNSIRHNLSLNECFVKVARDDKK 137
            ||..||:::|:|::||:.||:::::..||::|     :..||:|||||||||:..|::|  .::.
  Rat   162 LITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV--QNEG 224

  Fly   138 PGKGSYWTLDPD-----------SYNMFDNGSFLRRR-RRFKKKDVMREKEEA------------ 178
            .||.|:|.|:|:           :.:|.:|..|.:.| |..|||..::..:|.            
  Rat   225 TGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKW 289

  Fly   179 -IKRQAMMNEKLAEMKPLKLMTNGILEAKHMAAHAAHFKKEPLM----DLG-------------- 224
             ....:..|:........:..|:.       .|.....:..|:|    |||              
  Rat   290 PASPGSHSNDDFDNWSTFRPRTSS-------NASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAA 347

  Fly   225 -----CLSGKEVSHAAMLNSCHDS---LAQMNHLAGGGVEHPGFTVDSLM-------------NV 268
                 ..|..|:|:...:.:..|:   |:....|.......||    |:|             ::
  Rat   348 KMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPG----SMMQQTPCYSFAPPNTSL 408

  Fly   269 YNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHH-------AQQLQRHVA--------HVA 318
            .:|..:::.|.|  .:.:::.|....|..:..:.:::.       |..|.:.:.        .:.
  Rat   409 NSPSPNYAKYTY--GQSSMSPVPQMPMQTLQDSKSSYGGLNQYNCAPGLLKELLTSDSPPHNDIM 471

  Fly   319 HPLTPG----GQGAGGQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQ--GTPTHPGHN 377
            .|:.||    .....||:....|.::.    ||:|          ...|||...  .:.|||||.
  Rat   472 SPVDPGVAQPNSRVLGQNVLMGPNSVM----PAYG----------SQAPHNKMMNPSSHTHPGHA 522

  Fly   378 NNNSS 382
            ...||
  Rat   523 QQTSS 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crocNP_524202.1 FH_FOX 69..159 CDD:469596 38/132 (29%)
Foxo1NP_001178775.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..151 2/38 (5%)
FH_FOXO1 145..243 CDD:410834 34/99 (34%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 205..212 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..339 21/117 (18%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 228..231 1/2 (50%)
Nuclear localization signal. /evidence=ECO:0000250 245..247 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 277..557 44/278 (16%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 357..453 14/101 (14%)
FOXO_KIX_bdg 417..498 CDD:465228 12/82 (15%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 456..460 0/3 (0%)
FOXO-TAD 591..627 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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