DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and foxc1b

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_571804.1	Gene:	foxc1b / 79375	ZFINID:	ZDB-GENE-010302-2	Length:	433	Species:	Danio rerio

Alignment Length:	417	Identity:	162/417 - (38%)
Similarity:	210/417 - (50%)	Gaps:	77/417 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YAQTAAGYGSASAVAAASSASAAAAAHYAYDQYSRYPYS-ASAYGLGAP-HQNKEIVKPPYSYIA 77
            :.:||.|.|.....|..|.        |::..:.:||.. |.|||..|| .|.|::|||||||||
Zfish    25 FYRTATGGGYTGMPAPMSM--------YSHATHEQYPGGMARAYGPYAPAQQPKDMVKPPYSYIA 81

  Fly    78 LIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGS 142
            ||.|||||::|||:|||||||:||||||:|||||||||||||||||||||||||.||||||||||
Zfish    82 LITMAIQNSSDKKITLNGIYQFIMERFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGS 146

  Fly   143 YWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLA----EMKPLKLMTNGIL 203
            ||||||||||||:||||||||||||||||:||||:. .||...|...|    ..:|:||..   :
Zfish   147 YWTLDPDSYNMFENGSFLRRRRRFKKKDVLREKEDR-DRQGKDNPGQACEQDAQQPVKLRD---I 207

  Fly   204 EAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSLMNV 268
            :.::.|....|....||..:......:.|..:..:....|.....          .|::|::|..
Zfish   208 KTENGACTPPHDSTPPLSTVPKTESPDRSGGSACSGSPQSQTPQQ----------AFSMDTIMTG 262

  Fly   269 YNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHA----QQLQRHVAHVAHPLTPGGQGAG 329
            ......|:|   .|.....|...|..:.:......||::    |....|....|..|..|.:|.|
Zfish   263 LRGSPQHAA---ELPASRAALPGSVSLTYSPTPQPAHYSPPCGQPATYHCNMQATSLYTGDRGHG 324

  Fly   330 GQ-----SSGHSPTTISTPHGPAH-----------GGWYTPETPPSEPVPHNGQQG--TPTHPGH 376
            ..     ::..:.::||.||..:.           ..||         :..:|:.|  :.::||.
Zfish   325 DDTLPEYTNTTNASSISHPHQSSSQESQHLQQNRLAPWY---------LNQSGELGHLSASYPGQ 380

  Fly   377 NNN---------------NSSSVLNHN 388
            ..|               |||.|...|
Zfish   381 QQNFHAVREMFETQRIALNSSPVTGSN 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	78/85 (92%)
foxc1b	NP_571804.1	Forkhead	74..160	CDD:278670	78/85 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..250		19/79 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..355		7/36 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3591
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3317
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm26006
orthoMCL	1	0.900	-	-		OOG6_109214
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4522
SonicParanoid	1	1.000	-	-		X2290
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860