DRSC/TRiP Functional Genomics Resources

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Protein Alignment croc and Foxo3

DIOPT Version :10

Sequence 1:NP_524202.1 Gene:croc / 40374 FlyBaseID:FBgn0014143 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_062714.1 Gene:Foxo3 / 56484 MGIID:1890081 Length:672 Species:Mus musculus


Alignment Length:539 Identity:115/539 - (21%)
Similarity:193/539 - (35%) Gaps:160/539 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 GYGSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQ--NKEIVKPPYSYIALIAMAI 83
            |.|.||   ||.:.|..........|....|...:|.|.|.|.:  ::.......||..||..||
Mouse   108 GSGPAS---AAGALSGGTPTQLQPQQPLPQPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAI 169

  Fly    84 QNAADKKVTLNGIYQYIMERFPYYRD-----NKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSY 143
            :::.||::||:.||::::...||::|     :..||:|||||||||:..|::|  .::..||.|:
Mouse   170 ESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV--QNEGTGKSSW 232

  Fly   144 WTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMTNGILEAKHM 208
            |.::||.                      .:..:|.:|:|:..:.          :|...:::..
Mouse   233 WIINPDG----------------------GKSGKAPRRRAVSMDN----------SNKYTKSRGR 265

  Fly   209 AAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSLMNVYNPRI 273
            ||.                 |:.:..|...|..||.:|::...|.........:|:..: :..| 
Mouse   266 AAK-----------------KKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTD-FRSR- 311

  Fly   274 HHSAYPYHLNEDNLATV--------ASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTP--GGQGA 328
                     ...|.:||        ||:::..|.....                ||:|  ....|
Mouse   312 ---------TNSNASTVSGRLSPILASTELDDVQDDDG----------------PLSPMLYSSSA 351

  Fly   329 GGQSSGHSPTTISTPHGPAHGGWYTPE----------------TPPSEPVPHNG--QQGTPTHPG 375
            ....|...|.|:..|......|.....                .|||:|.|..|  |:|      
Mouse   352 SLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQPSPPGGLMQRG------ 410

  Fly   376 HNNNNSSSVLNHNGVGNGGGGGGGGGGGSSSV--LTSSPTSAL------GFRDMIFEQNQSCQ-- 430
               ::.......:|:|:..|.......|.||:  |..||...:      .|..:....||:.|  
Mouse   411 ---SSFPYTAKSSGLGSPTGSFNSTVFGPSSLNSLRQSPMQTIQENRPATFSSVSHYGNQTLQDL 472

  Fly   431 --LDTGSPTGSLQSASPP----ASASVAA-----------------ASAAAAAAVISSH--HHHH 470
              .|:.|.:..:.:.|.|    ||.:|:|                 |:.....::::.:  ||.|
Mouse   473 LASDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQH 537

  Fly   471 HHHAALSGNLGQLGQLSNL 489
            ....||.|:......:||:
Mouse   538 QTQGALGGSRALSNSVSNM 556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crocNP_524202.1 FH_FOX 69..159 CDD:469596 34/94 (36%)
Foxo3NP_062714.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..85
Required for mitochondrial import. /evidence=ECO:0000250|UniProtKB:O43524 80..108 115/539 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..152 12/44 (27%)
FH_FOXO3 156..238 CDD:410835 32/83 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..301 17/119 (14%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43524 241..258 3/26 (12%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000250|UniProtKB:O43524 299..672 55/294 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..441 11/50 (22%)
FOXO_KIX_bdg 431..510 CDD:465228 18/78 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..583 7/22 (32%)
FOXO-TAD 605..643 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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