DRSC/TRiP Functional Genomics Resources

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Protein Alignment croc and Foxo1

DIOPT Version :10

Sequence 1:NP_524202.1 Gene:croc / 40374 FlyBaseID:FBgn0014143 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_062713.2 Gene:Foxo1 / 56458 MGIID:1890077 Length:652 Species:Mus musculus


Alignment Length:536 Identity:111/536 - (20%)
Similarity:183/536 - (34%) Gaps:195/536 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FSDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYA-------YDQYSRYP-------YSAS 55
            |:..||.|...|.:.....:..|.|:.:||||.:....:       .:.::|.|       .:|:
Mouse    32 FNQSNSTTSSPAPSGGAAANPDAAASLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAA 96

  Fly    56 AYGLGAPHQNKE----------------IVKPP------------------------------YS 74
            :.||....|..|                :.:||                              .|
Mouse    97 SRGLCGDFQGPEAGCVHPAPPQPPPTGPLSQPPPVPPSAAAAAGPLAGQPRKTSSSRRNAWGNLS 161

  Fly    75 YIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRD-----NKQGWQNSIRHNLSLNECFVKVARD 134
            |..||..||:::|:|::||:.||:::::..||::|     :..||:|||||||||:..|::|  .
Mouse   162 YADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV--Q 224

  Fly   135 DKKPGKGSYWTLDPD-----------SYNMFDNGSFLRRR-RRFKKKDVMREKEEAIKRQAMMNE 187
            ::..||.|:|.|:|:           :.:|.:|..|.:.| |..|||..::..:|....      
Mouse   225 NEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGD------ 283

  Fly   188 KLAEMKPLKLMTNGILEAKHMAAHAAH----------FKKEPLMDLGCLSGKEVSHAAMLNSCHD 242
                       :.|...:|..|:..:|          |:.....:...:||:          ...
Mouse   284 -----------SPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGR----------LSP 327

  Fly   243 SLAQMNHLAGGGVE---HP------GFTVDSLMNVYNPRIHHSAYPYHLNEDNLATVASSQMHHV 298
            .:.:.:.|..|.|.   :|      ..|:.||..:.||....:..      |||..::|.....|
Mouse   328 IMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLL------DNLNLLSSPTSLTV 386

  Fly   299 HHAAAAHHAQQLQRHVAHVAHPLT------PG-GQGAGGQSSGHSP------------------- 337
            ...::.....| |......|.|.|      |. .:...|||| .||                   
Mouse   387 STQSSPGSMMQ-QTPCYSFAPPNTSLNSPSPNYSKYTYGQSS-MSPLPQMPMQTLQDSKSSYGGL 449

  Fly   338 ----------TTISTPHGPAHGGWYTPETP-----------------PSEPVPHNGQQ------- 368
                      ..:.|...|.|....:|..|                 |:..:|..|.|       
Mouse   450 NQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKMM 514

  Fly   369 --GTPTHPGHNNNNSS 382
              .:.|||||....:|
Mouse   515 NPSSHTHPGHAQQTAS 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crocNP_524202.1 FH_FOX 69..159 CDD:469596 38/135 (28%)
Foxo1NP_062713.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..154 2/41 (5%)
FH_FOXO1 148..246 CDD:410834 34/99 (34%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 208..215 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..342 23/137 (17%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 231..234 1/2 (50%)
Nuclear localization signal. /evidence=ECO:0000250 248..250 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393 280..562 48/286 (17%)
Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200 360..456 19/103 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..410 5/27 (19%)
FOXO_KIX_bdg 420..501 CDD:465228 12/81 (15%)
Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471 459..463 0/3 (0%)
FOXO-TAD 594..630 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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