DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and foxo6a

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_690041.2	Gene:	foxo6a / 561541	ZFINID:	ZDB-GENE-110914-126	Length:	594	Species:	Danio rerio

Alignment Length:	507	Identity:	113/507 - (22%)
Similarity:	174/507 - (34%)	Gaps:	172/507 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRD-----NKQGWQNSIRHNLSLNECFVKVAR 133
            ||..||..||::..||::||:.||.:::...||::|     :..||:|||||||||:..|::|
Zfish    96 SYAELITRAIESTPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRV-- 158

  Fly   134 DDKKPGKGSYWTLDPDSYNMFDNGSFLRRR--------RRFKKKDVMREKEEAIKRQAMMNEKLA 190
            .::..||.|:|.|:|:...:   |...|||        :..|.|.....|:...||: ...|.|.
Zfish   159 QNEGTGKSSWWMLNPEGGKL---GKSQRRRAVSMDNGIKPLKSKGRTNRKKTTGKRE-QSTETLL 219

  Fly   191 EM--KP----------------LKLMTNGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAML 237
            |.  .|                ..|.:.|......::.|.:     |::..|.|...|...
Zfish   220 EFCSSPDSGTGRIVVKDEFDTWTDLHSLGSSSTSTLSGHLS-----PILGEGELGEPEERR---- 275

  Fly   238 NSCHDSLAQMNHLAGGGVEHPGFTVDSLMNVYNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAA 302
            .||..|                           ||:..|....|....:..|...:.:.:..|.:
Zfish   276 KSCSAS---------------------------PRLFPSPSSAHSPASHCPTDLRATIGYKQHQS 313

  Fly   303 AAHHAQQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHGPAHG----GWYTPETPPSEPVP 363
            ..|.    ..|..:|:..          :|.|.|..|     .|.:|    |.:....|.:|  .
Zfish   314 PCHK----NPHYHYVSDI----------KSQGSSCET-----QPVYGLPDVGMHRSSIPTTE--D 357

  Fly   364 HNG-QQGTPT-----------------HPGHNNNNSSSVLNHNGVGNGGGGGGGGGGGSSSVLTS 410
            ::| .||..|                 |...|..:|..|                   |..:..|
Zfish   358 NSGSMQGASTIQNLLTTGPQQFVKEMMHGKENEVHSMMV-------------------SQGLHPS 403

  Fly   411 SP-TSALGFRDMIFEQNQSCQLD------TGSPT-GSLQS--------ASPPASASVAAASAAAA 459
            :| ||:..|.::|    ||...|      ...|| |.:||        .|||.:..:.|::|...
Zfish   404 NPNTSSKPFHNII----QSLSQDHRPTSVHSQPTDGHMQSYMHKSPYLYSPPVTVHLPASTALNP 464

  Fly   460 AAVISSHHHHHHHHAALSGNLGQLGQLSNLSHYRPHVGHY---QEYGIKYGV 508
            |.|              .|.......|:...:.:||...|   .|:.:.||:
Zfish   465 AGV--------------QGIAQDTCHLATTPYPQPHSYVYTDPHEHSLAYGL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	34/86 (40%)
foxo6a	XP_690041.2	FH	92..172	CDD:238016	32/77 (42%)
		PAT1	<390..>530	CDD:330585	32/150 (21%)
		FOXO-TAD	528..568	CDD:318811
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910