DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment croc and foxc1

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001007864.1	Gene:	foxc1 / 493250	XenbaseID:	XB-GENE-479055	Length:	495	Species:	Xenopus tropicalis

Alignment Length:	508	Identity:	177/508 - (34%)
Similarity:	247/508 - (48%)	Gaps:	115/508 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPH-QNKEIV 69
            |.:.|:.|..|..||..|..:.:||..|    ..:|.|::||.  ...|.|||...|. |.|::|
Frog    20 SGEQSYYRAAAAAAAAGGGYTGMAAPMS----MYSHPAHEQYQ--AGMARAYGPYTPQPQPKDMV 78

  Fly    70 KPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARD 134
            ||||||||||.||||||.:||:|||||||:||||||:|||||||||||||||||||||||||.||
Frog    79 KPPYSYIALITMAIQNAPEKKITLNGIYQFIMERFPFYRDNKQGWQNSIRHNLSLNECFVKVPRD 143

  Fly   135 DKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMR-----EKEEAIKRQAMMNEKLAEMKP 194
            ||||||||||||||||||||:||||||||||||||||::     :|:..:|.........|:.:
Frog   144 DKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVVKDATKEDKDRLLKEHHGSQPAAAQQQ- 207

  Fly   195 LKLMTNGILEAKHMAAHAAHFKKEP--LMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEH 257
             :....|..:|:..:.      .:|  :.|:...:|......||    ..:|:.:..     :|.
Frog   208 -RQQQQGQAQAEQDSG------SQPVRIQDIKTENGTSSPPQAM----SPALSTVPK-----IES 256

  Fly   258 PGFTVDSLMNVYNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLT 322
            |    ||..::      .|..|:.:..:...::.:::.||.|.  ..||:|...  |.::...|.
Frog   257 P----DSSSSM------SSGSPHSIPSNRSMSLEAAESHHPHQ--QHHHSQGFS--VDNIMTSLR 307

  Fly   323 PGGQGAG--------GQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNN 379
            ...||:|        ...:|.:|:::.| :.|..|..|:|  |.|:
Frog   308 GSPQGSGELPSPLISSSRTGIAPSSLLT-YSPGQGSIYSP--PCSQ------------------- 350

  Fly   380 NSSSVLNHNGVGNGGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQN-QSCQLDTGSPTGSLQSA 443
                     |..:|||.|                        .:..| |:..|.:|..:|.|..|
Frog   351 ---------GTSSGGGAG------------------------TYHCNMQAMSLYSGDRSGHLTPA 382

  Fly   444 SPPASASVA------AASAAAAAAVISSHHHHHHHHAALSGNLGQLGQLSNLS 490
            :.||:.:|.      :.:....:|:...:..|.|.....|..|.|.|.|.:|:
Frog   383 NTPAATTVEDTLPDYSITTTTTSALSHGNQEHPHQGRLPSWYLNQAGDLGHLA 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	78/85 (92%)
foxc1	NP_001007864.1	Forkhead	79..164	CDD:365978	77/84 (92%)
foxc1	NP_001007864.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..322		34/177 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3649
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3346
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm48915
Panther	1	1.100	-	-	LDO	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4522
SonicParanoid	1	1.000	-	-		X2290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100