DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment croc and foxc2

DIOPT Version :9

Sequence 1:NP_524202.1 Gene:croc / 40374 FlyBaseID:FBgn0014143 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_998857.1 Gene:foxc2 / 407875 XenbaseID:XB-GENE-481382 Length:463 Species:Xenopus tropicalis


Alignment Length:530 Identity:183/530 - (34%)
Similarity:249/530 - (46%) Gaps:115/530 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQ---NKE 67
            |:||     |.:.|..||         |.:...:.:.|::||:  |..|.:||....||   .|:
 Frog    20 SEQN-----YYRAAGTYG---------SMATPMSVYPAHEQYT--PGMARSYGPYHHHQPAAPKD 68

  Fly    68 IVKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVA 132
            :|||||||||||.||||||.|||:|||||||:||:|||:||:||||||||||||||||||||||.
 Frog    69 LVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVP 133

  Fly   133 RDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAI-KRQAMM----------- 185
            ||||||||||||||||||||||:||||||||||||||||.||||:.| |.|..:           
 Frog   134 RDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSREKEDRILKDQGKVQGPIPSLELPK 198

  Fly   186 -NEKL---AEMKPLKLMTNGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQ 246
             ::|:   :|...|.::|                |.|.|...|   |..:..:....:...|::.
 Frog   199 HDKKIVIKSESPELPVIT----------------KVENLSPDG---GSAMQDSPRSVASTPSVST 244

  Fly   247 MNHLAGGGVEHP---GFTVDSLMNV-YNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHA 307
            .|.:..   :||   ||:|:::|.: .:|  |....|..........|.|..:::....::.:  
 Frog   245 ENSIPD---QHPASNGFSVENIMTLRTSP--HGDLSPVPAVPCRTGMVPSLPINYTQTQSSVY-- 302

  Fly   308 QQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPT 372
                      :...|.....:|.........::           ||.:.|.....|...::.|..
 Frog   303 ----------SQACTQSMDTSGSYQCSMRAMSL-----------YTGDRPSHMCAPSTLEEATSD 346

  Fly   373 HPGHNNNNSSSVLNHNGVGNGGGGGGGGGGGSSSVLTSS---PTSALGFRDMIFEQNQSCQLD-- 432
            |    :|.::|.||...:|:          |..||||||   .|:..|.....:..|....:.  
 Frog   347 H----HNGTASPLNSMSLGS----------GQESVLTSSHHQQTATGGQTAAPWYLNPGADISHL 397

  Fly   433 TGSPTGSLQSASPPASASVAAASAAAAAAVISSHHHHHHHHAALSGNLG-QLGQLSNLSHYRPHV 496
            :|...||.|...|.......:......::.:|.|.        :|||.. |:...|..|.|| |.
 Frog   398 SGHNFGSQQQTFPNVREMFNSHRLGIESSALSEHQ--------VSGNTSCQIPYRSAPSIYR-HS 453

  Fly   497 GHYQEYGIKY 506
            ..|.....||
 Frog   454 SPYAYDCTKY 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crocNP_524202.1 Forkhead 70..156 CDD:278670 77/85 (91%)
foxc2NP_998857.1 Forkhead 71..156 CDD:306709 76/84 (90%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 173 1.000 Domainoid score I3649
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 232 1.000 Inparanoid score I3346
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 1 1.000 - - otm48915
Panther 1 1.100 - - O PTHR11829
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4522
SonicParanoid 1 1.000 - - X2290
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
99.100

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