DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment croc and foxa2

DIOPT Version :9

Sequence 1:NP_524202.1 Gene:croc / 40374 FlyBaseID:FBgn0014143 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_989423.1 Gene:foxa2 / 395063 XenbaseID:XB-GENE-480476 Length:434 Species:Xenopus tropicalis


Alignment Length:337 Identity:119/337 - (35%)
Similarity:168/337 - (49%) Gaps:52/337 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 AQTAAGYGSASAVA----AASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQNKE--------- 67
            |.|..|.|.||..:    :.|..||.|.:..|...|:.....:..||....:::::         
 Frog    82 AMTGMGTGVASMASHLSPSMSPMSAQATSMNALAPYTNMNSMSPIYGQSNINRSRDPKTYRRSYT 146

  Fly    68 IVKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVA 132
            ..|||||||:||.||||.:.:|.:||:.|||:||:.||:||.|:|.|||||||:||.|:||:||.
 Frog   147 HAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVP 211

  Fly   133 RDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFK--KKDVMREKEEAIKRQAMMNEKLAE-MKP 194
            |...||||||:|||.|||.|||:||.:|||::|||  ||..:||..         .:||:| ...
 Frog   212 RSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKKPSLREGG---------GKKLSEGSSS 267

  Fly   195 LKLMTNGILEAK------HMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGG 253
            :....|...|:.      |.::.....:|..|:|:....|....|||      ...:|..||.. 
 Frog   268 VGSAANSSSESSVGNESPHSSSSPCQEQKRSLVDMKSSQGLSPDHAA------SPASQAQHLLS- 325

  Fly   254 GVEHPGFTVDSLMNVYNPRIHHS-AYPYHLNEDNLATVASSQMHHVHHAAAAHH-------AQQL 310
              :|.........:...|..|:| .:|:.:|  ||  ::|.|.||.||....||       |.:.
 Frog   326 --QHHSVLSHEAQSHLKPEHHYSFNHPFSIN--NL--MSSEQQHHHHHHHNHHHHHKMDLKAYEQ 384

  Fly   311 QRHVAHVAHPLT 322
            ..|.:....|:|
 Frog   385 VMHYSGYGSPMT 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crocNP_524202.1 Forkhead 70..156 CDD:278670 57/85 (67%)
foxa2NP_989423.1 Forkhead_N 17..148 CDD:369872 14/65 (22%)
FH 149..237 CDD:214627 58/87 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 249..339 21/107 (20%)
HNF_C 349..423 CDD:370449 16/52 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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