DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and Foxc1

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_599165.1	Gene:	Foxc1 / 364706	RGDID:	1589718	Length:	553	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	195/523 - (37%)
Similarity:	248/523 - (47%)	Gaps:	116/523 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YGSASAVAAASSASAAAA-----AHYAYDQYSRYPYS-ASAYGLGAPH-QNKEIVKPPYSYIALI 79
            |..|:|.||....:|..|     :|.|:.:  :||.. |.|||...|. |.|::|||||||||||
  Rat    25 YYRAAAAAAGGGYTAMPAPMSVYSHPAHAE--QYPGGMARAYGPYTPQPQPKDMVKPPYSYIALI 87

  Fly    80 AMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYW 144
            .||||||.|||:|||||||:||:|||:|||||||||||||||||||||||||.||||||||||||
  Rat    88 TMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYW 152

  Fly   145 TLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMTNGILEAKHMA 209
            ||||||||||:|||||||||||||||.:::|||..:..      |.|..|.:............|
  Rat   153 TLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLH------LQEPPPPQAGRQPAPAPPEQA 211

  Fly   210 AHAAHFKKEP---LMDLGCLSG------KEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSL 265
            ..:|...::|   :.|:...:|      :.:|.||.|.|  .|.|.:..     :|.|..:..||
  Rat   212 EGSAPGPQQPPVRIQDIKTENGTCPSPPQPLSPAAALGS--GSAATVPK-----IESPDSSSSSL 269

  Fly   266 MNVYN-PRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQG-- 327
            .:..: |....||.|..|:       |:........|...||:|...  |.::...|....||
  Rat   270 SSGSSPPGSLPSARPLSLD-------AAEPAPPPQPAPPPHHSQGFS--VDNIMTSLRGSPQGSA 325

  Fly   328 -----------AGGQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNS 381
                       |....:|.:|......:.|.|...|:  :|.|:                    |
  Rat   326 AELGSGLLASAAASSRAGIAPPLALGAYSPGHSSLYS--SPCSQ--------------------S 368

  Fly   382 SSVLNHNGVGNGGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGS----------- 435
            ||.    |...||||||||||||||...:...:           ...|.|...|
  Rat   369 SSA----GSSGGGGGGGGGGGGSSSAAGTGGAA-----------TYHCNLQAMSLYAAGERGGHL 418

  Fly   436 --PTGSLQSAS----------PPASASVAAASAAAAAAVISSHHHHHHHHAALSGNLGQLGQLSN 488
              |.|...||:          |||::|.:::.:.......:|||...|.....|..|.|.|  .:
  Rat   419 QGPAGGGGSAAVDDPLPDYSLPPATSSSSSSLSHGGGGQETSHHPASHQGRLTSWYLNQAG--GD 481

  Fly   489 LSH 491
            |.|
  Rat   482 LGH 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	78/85 (92%)
Foxc1	NP_599165.1	FH	78..166	CDD:214627	79/87 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3578
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3240
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm45825
orthoMCL	1	0.900	-	-		OOG6_109214
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2290
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870