Protein Alignment croc and FOXA2

DIOPT Version :10

• Sequence 1: NP_524202.1
• Gene: croc / 40374
• FlyBaseID: FBgn0014143
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_068556.2
• Gene: FOXA2 / 3170
• HGNCID: 5022
• Length: 463
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 143/521 - (27%)
• Similarity: 176/521 - (33%)
• Gaps: 234/521 - (44%)

  Fly    16 AQTAAGYG-----SASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQNKEI------V 69
            |...||.|     |.|.:...::.:....|.|| :..|..|....| ||......|..      .
Human   102 AAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYA-NMNSMSPMYGQA-GLSRARDPKTYRRSYTHA 164

  Fly    70 KPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARD 134
            |||||||:||.||||.:.:|.:||:.|||:||:.||:||.|:|.|||||||:||.|:||:||.|.
Human   165 KPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRS 229

  Fly   135 DKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMT 199
            ..||||||:|||.|||.|||:||.:|||::|||     .||:.|:|.
Human   230 PDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFK-----CEKQLALKE------------------ 271

  Fly   200 NGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDS 264
                     ||.||.            |||:.:..|..     |.||:...||...|.|..|...
Human   272 ---------AAGAAG------------SGKKAAAGAQA-----SQAQLGEAAGPASETPAGTESP 310

  Fly   265 LMNVYNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAG 329
                     |.||.|                              .|.|           .:|..
Human   311 ---------HSSASP------------------------------CQEH-----------KRGGL 325

  Fly   330 GQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQ--------GTPTHPG-----HNNNNS 381
            |:..|.....:|                |.||.|..|||        |.|.|||     |.....
Human   326 GELKGTPAAALS----------------PPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEH 374

  Fly   382 SSVLNHNGVGNGGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSPTGSLQSASPP 446
            ....||                        |.|                      ..:|.|:.
Human   375 HYAFNH------------------------PFS----------------------INNLMSSE-- 391

  Fly   447 ASASVAAASAAAAAAVISSHHHHHHHHAALSGNLGQLGQLSNLSHYRPH---------VGHYQEY 502
                             ..|||.||||                   :||         |.||..|
Human   392 -----------------QQHHHSHHHH-------------------QPHKMDLKAYEQVMHYPGY 420

  Fly   503 G 503
            |
Human   421 G 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	FH_FOX	69..159	CDD:469596	59/89 (66%)
FOXA2	NP_068556.2	Forkhead_N	23..164	CDD:369872	15/63 (24%)
		FH_FOXA2	163..264	CDD:410813	65/105 (62%)
		HNF_C	379..452	CDD:430552	20/127 (16%)