Protein Alignment croc and FOXA1

DIOPT Version :10

• Sequence 1: NP_524202.1
• Gene: croc / 40374
• FlyBaseID: FBgn0014143
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_004487.2
• Gene: FOXA1 / 3169
• HGNCID: 5021
• Length: 472
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 155/534 - (29%)
• Similarity: 195/534 - (36%)
• Gaps: 190/534 - (35%)

  Fly     1 MHTLFSDQN----SFTRHYAQTAAGYG-SASAVAAASSASAAA---------------------- 38
            |:|:.:..|    ||...||....|.| |..|||.....||.|
Human    50 MNTMTTSGNMTPASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMG 114

  Fly    39 --AAHYAYDQYSRYPYSAS--------AY---GLGA----------------PHQNKEIVKPPYS 74
              .|..|.......||:|:        ||   .||.                ||     .|||||
Human   115 AMGAQQAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPH-----AKPPYS 174

  Fly    75 YIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPG 139
            ||:||.||||.|..|.:||:.|||:||:.|||||.|:|.|||||||:||.|:|||||||...|||
Human   175 YISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPG 239

  Fly   140 KGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMTNGILE 204
            |||||||.|||.|||:||.:|||::|||                      .|.:|......|...
Human   240 KGSYWTLHPDSGNMFENGCYLRRQKRFK----------------------CEKQPGAGGGGGSGS 282

  Fly   205 AKHMAAHAAHFKKEPLMDLGCLSG--KEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSLMN 267
            ....|......:|:|       ||  ...:.:.:....|....|:.     |...||
Human   283 GGSGAKGGPESRKDP-------SGASNPSADSPLHRGVHGKTGQLE-----GAPAPG-------- 327

  Fly   268 VYNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAGGQS 332
                   .:|.|..|:...              |.|...|.:|:...:..|.|::.|........
Human   328 -------PAASPQTLDHSG--------------ATATGGASELKTPASSTAPPISSGPGALASVP 371

  Fly   333 SGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQ---QGTP----THP-GHNNNNSSSVLNHNG 389
            :.|          ||||           ..||..|   :|.|    .|| ..||..|||...|.
Human   372 ASH----------PAHG-----------LAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHK- 414

  Fly   390 VGNGGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSPTGSLQSAS-PPASASVAA 453
                                      |.|:    ...|:.|.   ||.||...|| |..||||..
Human   415 --------------------------LDFK----AYEQALQY---SPYGSTLPASLPLGSASVTT 446

  Fly   454 ASAAAAAAVISSHH 467
            .|....:|:..:::
Human   447 RSPIEPSALEPAYY 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	FH_FOX	69..159	CDD:469596	64/89 (72%)
FOXA1	NP_004487.2	Forkhead_N	17..169	CDD:369872	27/123 (22%)
		FH_FOXA1	157..268	CDD:410812	72/137 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..392		32/184 (17%)
		HNF_C	397..461	CDD:430552	25/98 (26%)