DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and fkh2

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_596764.1	Gene:	fkh2 / 2539703	PomBaseID:	SPBC16G5.15c	Length:	642	Species:	Schizosaccharomyces pombe

Alignment Length:	472	Identity:	113/472 - (23%)
Similarity:	163/472 - (34%)	Gaps:	147/472 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ASAYGLGAPHQNKEIVKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSI 118
            |:.||     .||   ||||||..:||.||.::::..:||:.||.:|...:||||..|.||||||
pombe   215 AAEYG-----DNK---KPPYSYSVMIAQAILSSSECMMTLSNIYSWISTHYPYYRTTKSGWQNSI 271

  Fly   119 RHNLSLNECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQA 183
            |||||||:.|.||.|...:.|||..|::.|:.     ...|:.:.|:..:|   |.....:...|
pombe   272 RHNLSLNKAFRKVPRKSGEQGKGMKWSIVPEF-----REEFIAKTRKTPRK---RSPSSPVPLLA 328

  Fly   184 MMNEKLAEMKPLKLMTNGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMN 248
            ...|....: |:.::.    :.|..:..||    ||              |:...|..|......
pombe   329 KKREGSPSL-PIPILP----KMKDTSIPAA----EP--------------ASSTTSARDQTPSTP 370

  Fly   249 HLAGGGVEHPGFTVDSLMNVYNPRIHHSAYPYHLNEDNLATVASSQMHHVH-HAAAAHHAQQLQR 312
            ...|..........:..|..|....|               .|.|.:...| :|..|:.|.|.::
pombe   371 KDVGSPSTAETSAEEKQMETYKTPTH---------------AALSDIISTHDYALDANSASQTKK 420

  Fly   313 HVAHVAHPLTPGGQGAGGQSSGHS--PTT----------ISTPHGPAHGGWYTPETPPSEPV-PH 364
                          .|.|...|.|  ||:          :..||.....|.|...:|...|| .|
pombe   421 --------------AAFGSPIGSSTYPTSSPAPFWKYVAVPNPHDWPQVGSYDTISPYRNPVNSH 471

  Fly   365 ---------------------------NGQQG------------------TPTHPGHNNNNSSSV 384
                                       ||.:|                  :||....|:|:.||.
pombe   472 LIYSQIQQSSPKKIDEQLHDLQGVDLVNGFEGISSWRESMVNKLRSSVSDSPTMNLANSNSKSSP 536

  Fly   385 LNHNGVGN-GGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQ--LDTG------------ 434
            :....|.. .............|.:::|||.    :....|.||:.:  ||..
pombe   537 VAVQRVSTLPQASANKQAKEMESKMSNSPTQ----KSKTEENNQAVRAILDASATMEKQYDLHRL 597

  Fly   435 -SPTGSLQSASPPASAS 450
             :||...:|||.|..|:
pombe   598 PTPTSQTESASVPQIAN 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	42/85 (49%)
fkh2	NP_596764.1	COG5025	6..622	CDD:227358	113/472 (24%)
		FHA	81..185	CDD:238017
		Forkhead	223..308	CDD:278670	42/89 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	104	1.000	Domainoid score	I1720
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm47009
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810