DRSC/TRiP Functional Genomics Resources

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Protein Alignment croc and FOXO3

DIOPT Version :10

Sequence 1:NP_524202.1 Gene:croc / 40374 FlyBaseID:FBgn0014143 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens


Alignment Length:527 Identity:116/527 - (22%)
Similarity:195/527 - (37%) Gaps:138/527 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 GSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQ--NKEIVKPPYSYIALIAMAIQN 85
            ||..| .||...|....|.....|....|...:|.|.|.|.:  ::.......||..||..||::
Human   109 GSGPA-TAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIES 172

  Fly    86 AADKKVTLNGIYQYIMERFPYYRD-----NKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWT 145
            :.||::||:.||::::...||::|     :..||:|||||||||:..|::|  .::..||.|:|.
Human   173 SPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV--QNEGTGKSSWWI 235

  Fly   146 LDPD-----------SYNMFDNGSFLRRR-RRFKKKDVMREKEEAI------------KRQAMMN 186
            ::||           :.:|.::..:.:.| |..|||..::...|:.            ...:..:
Human   236 INPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSS 300

  Fly   187 EKLAEMKPLKLMTNGILEAKHMAAHAAHFKKEPLM---DLGCLSGKEVSHAAMLNSCHDSLAQMN 248
            ::|......:..||.       .|.....:..|:|   :|..:...:...:.||.|...||:.  
Human   301 DELDAWTDFRSRTNS-------NASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSP-- 356

  Fly   249 HLAGGGVEHPGFTVDSLMNVYNPRIHHSAYPYHLNE-----------DNLATVASSQMHHVHHAA 302
                        :|.....|..||:...|...:||:           ||: |:..||        
Human   357 ------------SVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNI-TLPPSQ-------- 400

  Fly   303 AAHHAQQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQ 367
            .:.....:||   ..:.|.|..|.|.|..:|..:    ||..||:  ...:....|.:.:..| :
Human   401 PSPTGGLMQR---SSSFPYTTKGSGLGSPTSSFN----STVFGPS--SLNSLRQSPMQTIQEN-K 455

  Fly   368 QGTPTHPGHNNNN------SSSVLNHNGVGNGGGGGGGGGGGSSSVLT---------SSPTSALG 417
            ..|.:...|..|.      :|..|:|:.|                ::|         |:..||..
Human   456 PATFSSMSHYGNQTLQDLLTSDSLSHSDV----------------MMTQSDPLMSQASTAVSAQN 504

  Fly   418 FRDMIFEQNQSCQLDTGSPTGSLQSASPPASASVAAASAAAAAAVISSHHHHHHHHAALSGNLGQ 482
            .|..:..:|..          .:..|:.|...|:...:..         ||.|....||.|:...
Human   505 SRRNVMLRNDP----------MMSFAAQPNQGSLVNQNLL---------HHQHQTQGALGGSRAL 550

  Fly   483 LGQLSNL 489
            ...:||:
Human   551 SNSVSNM 557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crocNP_524202.1 FH_FOX 69..159 CDD:469596 35/105 (33%)
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 13/44 (30%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 32/83 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 11/70 (16%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 1/16 (6%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 62/333 (19%)
FOXO_KIX_bdg 432..511 CDD:465228 18/97 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 7/22 (32%)
FOXO-TAD 606..644 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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