DRSC/TRiP Functional Genomics Resources

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Protein Alignment croc and FOXO1

DIOPT Version :10

Sequence 1:NP_524202.1 Gene:croc / 40374 FlyBaseID:FBgn0014143 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens


Alignment Length:543 Identity:128/543 - (23%)
Similarity:195/543 - (35%) Gaps:171/543 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FSDQNSFTRHYA---------QTAAGYGSASA--------------------------VAAASSA 34
            ||..||.|...|         ..|||..||||                          ||||.:|
Human    32 FSQSNSATSSPAPSGSAAANPDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAA 96

  Fly    35 SAAAAA----------------HYA---------YDQYSRYPYSASAYGLGAPHQNKEIVKPPY- 73
            :|||||                |.|         ..|:...|.:|:....|.|.::....:..: 
Human    97 AAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWG 161

  Fly    74 --SYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRD-----NKQGWQNSIRHNLSLNECFVKV 131
              ||..||..||:::|:|::||:.||:::::..||::|     :..||:|||||||||:..|::|
Human   162 NLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV 226

  Fly   132 ARDDKKPGKGSYWTLDPD-----------SYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMM 185
              .::..||.|:|.|:|:           :.:|.:|..|.:.|.|..||          |.....
Human   227 --QNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKK----------KASLQS 279

  Fly   186 NEKLAEMKPLKLMTNGILEAKHMAAHAAH----------FKKEPLMDLGCLSGKEVSHAAMLNSC 240
            .::.|...|      |...:|..|:..:|          |:.....:...:||:          .
Human   280 GQEGAGDSP------GSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGR----------L 328

  Fly   241 HDSLAQMNHLAGGGVE---HP------GFTVDSLMNVYNPRIHHSAYPYHLNEDNLATVASSQMH 296
            ...:.:.:.|..|.|.   :|      ..|:.||..:.||....:..      |||..::|....
Human   329 SPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLL------DNLNLLSSPTSL 387

  Fly   297 HVHHAAAAHHAQQLQRHVAHVAHPLT------PGGQG-AGGQSS----GHSPTTISTPHGPAHGG 350
            .|...::.....| |......|.|.|      |..|. ..||||    ...|......:..::||
Human   388 TVSTQSSPGTMMQ-QTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGG 451

  Fly   351 WYTPETPP--------SEPVPHNGQQGTPTHPGHNNNNS-----------SSVL-------NHNG 389
            .......|        |:..|||... ||..||....||           :||:       :||.
Human   452 MSQYNCAPGLLKELLTSDSPPHNDIM-TPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNK 515

  Fly   390 VGNGGGGGGGGGGGSSSVLTSSP 412
            :.|.......|....:|.:...|
Human   516 MMNPSSHTHPGHAQQTSAVNGRP 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crocNP_524202.1 FH_FOX 69..159 CDD:469596 36/108 (33%)
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 11/30 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158 7/41 (17%)
FH_FOXO1 151..249 CDD:410834 34/99 (34%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 23/135 (17%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 1/2 (50%)
Nuclear localization signal 251..253 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 56/280 (20%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459 21/102 (21%)
FOXO_KIX_bdg 423..504 CDD:465228 19/81 (23%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537 5/29 (17%)
FOXO-TAD 597..633 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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