DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and FOXC2

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_005242.1	Gene:	FOXC2 / 2303	HGNCID:	3801	Length:	501	Species:	Homo sapiens

Alignment Length:	522	Identity:	186/522 - (35%)
Similarity:	238/522 - (45%)	Gaps:	130/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLG---APHQN-- 65
            |:||     |.:.|..||..::....               ||.:|...|| |:|   ||:.:
Human    20 SEQN-----YYRAAGSYGGMASPMGV---------------YSGHPEQYSA-GMGRSYAPYHHHQ 63

  Fly    66 ----KEIVKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNE 126
                |::|||||||||||.||||||.:||:|||||||:||:|||:||:|||||||||||||||||
Human    64 PAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNE 128

  Fly   127 CFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAE 191
            |||||.||||||||||||||||||||||:||||||||||||||||.:||||    :|.:.|
Human   129 CFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSKEKEE----RAHLKE---- 185

  Fly   192 MKPLKLMTNGILEAKHMA-------------AHAAH------FKKEPLMDLGCLSGKEVSHAAM- 236
              |....:.|.....|:|             :.||.      .|.|.|.....|.|...|.|:.
Human   186 --PPPAASKGAPATPHLADAPKEAEKKVVIKSEAASPALPVITKVETLSPESALQGSPRSAASTP 248

  Fly   237 LNSCHDSLAQMNHLAGGGVEHPGFTVDSLMNV--------YNPRIHHS-------AYPYHLN--- 283
            ..|...||.:.:..|..|:  |||:|:::|.:        .:|....:       |.||...
Human   249 AGSPDGSLPEHHAAAPNGL--PGFSVENIMTLRTSPPGGELSPGAGRAGLVVPPLALPYAAAPPA 311

  Fly   284 ------EDNLATVASSQMHHVHHAAAAHHAQQLQRHVA-----------HVAHPLTPGGQGAGGQ 331
                  ...|...|:........|.:.:...:...|:.           |.:.|.:|  ..|...
Human   312 AYGQPCAQGLEAGAAGGYQCSMRAMSLYTGAERPAHMCVPPALDEALSDHPSGPTSP--LSALNL 374

  Fly   332 SSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNSSS-VLNHNGVGNGGG 395
            ::|......:|.|...|.|.:.|:.||..|.|.  .|.|| .||.....::| .|||:|..|...
Human   375 AAGQEGALAATGHHHQHHGHHHPQAPPPPPAPQ--PQPTP-QPGAAAAQAASWYLNHSGDLNHLP 436

  Fly   396 GGGGGG-----------------GGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSPTGSLQSA 443
            |.....                 |..:|.|..|..|.          |.||||...|.....:.|
Human   437 GHTFAAQQQTFPNVREMFNSHRLGIENSTLGESQVSG----------NASCQLPYRSTPPLYRHA 491

  Fly   444 SP 445
            :|
Human   492 AP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	76/85 (89%)
FOXC2	NP_005242.1	FH	72..160	CDD:214627	77/87 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..208		17/50 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..268		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..420		14/39 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159338
Domainoid	1	1.000	174	1.000	Domainoid score	I3687
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3426
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm41696
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4522
SonicParanoid	1	1.000	-	-		X2290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.030