DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and FOXC1

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001444.2	Gene:	FOXC1 / 2296	HGNCID:	3800	Length:	553	Species:	Homo sapiens

Alignment Length:	570	Identity:	199/570 - (34%)
Similarity:	263/570 - (46%)	Gaps:	151/570 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YGSASAVAAASSASAAAA-----AHYAYDQYSRYPYS-ASAYGLGAPH-QNKEIVKPPYSYIALI 79
            |..|:|.||....:|..|     :|.|:.:  :||.. |.|||...|. |.|::|||||||||||
Human    25 YYRAAAAAAGGGYTAMPAPMSVYSHPAHAE--QYPGGMARAYGPYTPQPQPKDMVKPPYSYIALI 87

  Fly    80 AMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYW 144
            .||||||.|||:|||||||:||:|||:|||||||||||||||||||||||||.||||||||||||
Human    88 TMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYW 152

  Fly   145 TLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEE------------------AIKRQAMMNEKLAE 191
            ||||||||||:|||||||||||||||.:::|||                  |...||..|....:
Human   153 TLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGRQPPPAPPEQADGNAPGPQ 217

  Fly   192 MKPLKLM----TNGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAG 252
            ..|:::.    .||...:          ..:||.....|.....:....:.|...|.:.::
Human   218 PPPVRIQDIKTENGTCPS----------PPQPLSPAAALGSGSAAAVPKIESPDSSSSSLS---- 268

  Fly   253 GGVEHPG-------FTVDSLMNVYNPRIHHSAYPYH---LNEDNLAT-------VASSQMHHVHH 300
            .|...||       .::|...:...|....:..|:|   .:.||:.|       .|::::.....
Human   269 SGSSPPGSLPSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAELSSGLL 333

  Fly   301 AAAAHHAQQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHGPAHGG--------------- 350
            |:||..::      |.:|.||..|....|..|...||.:.::..|.:.||
Human   334 ASAAASSR------AGIAPPLALGAYSPGQSSLYSSPCSQTSSAGSSGGGGGGAGAAGGAGGAGT 392

  Fly   351 ---------WYTPETPPSEPVPHNGQQGTPTHPGHN--------------NNNSSSVLNHNGVGN 392
                     .|.    ..|...|  .||.|...|.:              .::|||.|:|
Human   393 YHCNLQAMSLYA----AGERGGH--LQGAPGGAGGSAVDDPLPDYSLPPVTSSSSSSLSH----- 446

  Fly   393 GGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSPTGSLQSASPPASASVAAASAA 457
             ||||||||||..:  ...|.:..| |...:..||:     |...|.|           |:|:||
Human   447 -GGGGGGGGGGQEA--GHHPAAHQG-RLTSWYLNQA-----GGDLGHL-----------ASAAAA 491

  Fly   458 AAAAVISSHHHHHH-------------HHAALSGNLG-QLGQLSNLSHYR 493
            ||||.......:.|             :::.::||.. |:...|:.|.||
Human   492 AAAAGYPGQQQNFHSVREMFESQRIGLNNSPVNGNSSCQMAFPSSQSLYR 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	78/85 (92%)
FOXC1	NP_001444.2	Required for transcriptional activation. /evidence=ECO:0000269\|PubMed:11782474	1..51		8/25 (32%)
		FH	78..166	CDD:214627	79/87 (91%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269\|PubMed:11782474	78..93		13/14 (93%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269\|PubMed:11782474	168..176		7/7 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..310		28/150 (19%)
		Required for transcriptional inhibition. /evidence=ECO:0000269\|PubMed:11782474	215..366		31/170 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..387		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..465		19/58 (33%)
		Required for transcriptional activation. /evidence=ECO:0000269\|PubMed:11782474	466..553		23/93 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3687
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3426
Isobase	1	0.950	-	0	Normalized mean entropy	S2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm41696
orthoMCL	1	0.900	-	-		OOG6_109214
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4522
SonicParanoid	1	1.000	-	-		X2290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.950