Protein Alignment croc and FOXG1

DIOPT Version :10

• Sequence 1: NP_524202.1
• Gene: croc / 40374
• FlyBaseID: FBgn0014143
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_005240.3
• Gene: FOXG1 / 2290
• HGNCID: 3811
• Length: 489
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 112/353 - (31%)
• Similarity: 155/353 - (43%)
• Gaps: 76/353 - (21%)

  Fly    64 QNKEIVKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECF 128
            :|.:..|||:||.|||.|||:.:.:|::||||||::||:.|||||:||||||||||||||||:||
Human   175 KNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCF 239

  Fly   129 VKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMK 193
            |||.|....||||:||.|||.|.::|..|:..:.||                |......|||..:
Human   240 VKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRR----------------RSTTSRAKLAFKR 288

  Fly   194 PLKLMTNGILEAKHMAAHAAHFKKEPLMDL------GCLSGKEVSHAAMLNSC-HDSLAQMNHLA 251
            ..:|.:.|:.....  |.:.::...|.:.|      ..||....:.|...:.. :.|:...|.|
Human   289 GARLTSTGLTFMDR--AGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSL- 350

  Fly   252 GGGVEHP-----GFTVDSLMNVYNPRIHHSAYPYHLNEDNLA-------TVASSQMHHVHHAAAA 304
              |..|.     |.:||.|:|...|...|     ||....||       :|..|..:.::..:..
Human   351 --GNNHSFSTANGLSVDRLVNGEIPYATH-----HLTAAALAASVPCGLSVPCSGTYSLNPCSVN 408

  Fly   305 HHAQQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQG 369
            ..|.|......||.||          ..:..|.|::|.....:......|.|.|.|.:
Human   409 LLAGQTSYFFPHVPHP----------SMTSQSSTSMSARAASSSTSPQAPSTLPCESL------- 456

  Fly   370 TPTHPG--------------HNNNNSSS 383
            .|:.|.              |.|..|||
Human   457 RPSLPSFTTGLSGGLSDYFTHQNQGSSS 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	FH_FOX	69..159	CDD:469596	59/89 (66%)
FOXG1	NP_005240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..181		1/5 (20%)
		FH_FOXG	181..259	CDD:410795	54/77 (70%)
		COG5025	<184..>356	CDD:227358	75/192 (39%)
		Required for interaction with TLE6. /evidence=ECO:0000250|UniProtKB:Q60987	249..344		26/112 (23%)
		Interaction with KDM5B. /evidence=ECO:0000269|PubMed:12657635	383..406		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..455		6/27 (22%)