Protein Alignment croc and FOXK1

DIOPT Version :9

• Sequence 1: NP_524202.1
• Gene: croc / 40374
• FlyBaseID: FBgn0014143
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001032242.1
• Gene: FOXK1 / 221937
• HGNCID: 23480
• Length: 733
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 124/520 - (23%)
• Similarity: 192/520 - (36%)
• Gaps: 165/520 - (31%)

  Fly    21 GYGSAS-----AVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQNKEIVKPPYSYIALIA 80
            |.||:|     .|.:....:|..||..|.:|      .|...|..:|   |:..|||:||..||.
Human   260 GAGSSSYRFVQNVTSDLQLAAEFAAKAASEQ------QADTSGGDSP---KDESKPPFSYAQLIV 315

  Fly    81 MAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWT 145
            .||.:|.|:::||:|||.:|.:.:||||...:|||||||||||||..|:||.|..::|||||:|.
Human   316 QAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWR 380

  Fly   146 LDPDSYNMFDNGSFLRRRRR---------------------------------FKKKDVMREKEE 177
            :||.|.......:|.:||:|                                 .:..:.:..:..
Human   381 IDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSGGLQTPECLSREGS 445

  Fly   178 AIKRQAMMNEKLAEM--------------------------------KPLKLMTNGILEAKHMAA 210
            .|........|||.:                                ||:..|...|:.::..|.
Human   446 PIPHDPEFGSKLASVPEYRYSQSAPGSPVSAQPVIMAVPPRPSSLVAKPVAYMPASIVTSQQPAG 510

  Fly   211 HAAH-FKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSLMN-----VY 269
            ||.| .::.|.:.:    .:.|:.:|  ||.:..:......|||..:..|..|..|.:     ..
Human   511 HAIHVVQQAPTVTM----VRVVTTSA--NSANGYILTSQGAAGGSHDAAGAAVLDLGSEARGLEE 569

  Fly   270 NPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAGGQSSG 334
            .|.|..:..|   ....:....:|||           |..:..|...:..|.|
Human   570 KPTIAFATIP---AAGGVIQTVASQM-----------APGVPGHTVTILQPAT------------ 608

  Fly   335 HSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNSSSVLNHNGVGNGGGGGGG 399
              |.|:...|.|...            |..||:...||       ||.:
Human   609 --PVTLGQHHLPVRA------------VTQNGKHAVPT-------NSLA---------------- 636

  Fly   400 GGGGSSSVLTSS----PTSALGFRDMIFEQNQSCQLDTGSPTGSL--QSASPPASASVAAASAAA 458
               |::..|||.    .|.|.....::.  .:.|::....|..::  .:.:.||:|:.|:|||::
Human   637 ---GNAYALTSPLQLLATQASSSAPVVV--TRVCEVGPKEPAAAVAATATTTPATATTASASASS 696

  Fly   459  458
            Human   697  696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	47/85 (55%)
FOXK1	NP_001032242.1	Interaction with SIN3A and SIN3B. /evidence=ECO:0000250|UniProtKB:P42128	2..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..79
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000250|UniProtKB:P42128	95..420		65/168 (39%)
		FHA	<102..204	CDD:224630
		FHA	110..203	CDD:238017
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..306		6/27 (22%)
		Forkhead	305..391	CDD:278670	47/85 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..436		0/22 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..733		7/21 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820