DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and Foxk1

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_951031.2	Gene:	Foxk1 / 17425	MGIID:	1347488	Length:	719	Species:	Mus musculus

Alignment Length:	525	Identity:	127/525 - (24%)
Similarity:	185/525 - (35%)	Gaps:	180/525 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GYGSAS-----AVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQNKEIVKPPYSYIALIA 80
            |.||:|     .|.:....:|..||..|.:|      .|.|.|..:|   |:..||||||..||.
Mouse   246 GAGSSSYRFVQNVTSDLQLAAEFAAKAASEQ------QADASGGDSP---KDESKPPYSYAQLIV 301

  Fly    81 MAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWT 145
            .||.:|.|:::||:|||.:|.:.:||||...:|||||||||||||..|:||.|..::|||||:|.
Mouse   302 QAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWR 366

  Fly   146 LDPDSYNMFDNGSFLRRRRR---------------------------------FKKKDVMREKEE 177
            :||.|.......:|.:||:|                                 .:..:.:..:..
Mouse   367 IDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSSGLQTPECLSREGS 431

  Fly   178 AIKRQAMMNEKLAEM--------------------------------KPLKLMTNGILEAKHMAA 210
            .|.....:..|||.:                                ||:..|...|:.::..:.
Mouse   432 PIPHDPDLGSKLASVPEYRYSQSAPGSPVSAQPVIMAVPPRPSNLVAKPVAYMPASIVTSQQPSG 496

  Fly   211 HAAH-FKKEPLMDL--------GCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSLM 266
            ||.| .::.|.:.:        ...:|..::......:.||:       ||..|...|.....|.
Mouse   497 HAIHVVQQAPTVTMVRVVTTSANSANGYILASQGSTGTSHDT-------AGTAVLDLGNEARGLE 554

  Fly   267 NVYNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAGGQ 331
            .  .|.|..:..|           |:|:   |....|:..|..:..|...:..|.|
Mouse   555 E--KPTIAFATIP-----------AASR---VIQTVASQMAPGVPGHTVTILQPAT--------- 594

  Fly   332 SSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNSSSVLNHNGVGNGGGG 396
                 |.||...|.|...            |..||:...||       ||.:       ||
Mouse   595 -----PVTIGQHHLPVRA------------VTQNGKHAVPT-------NSLT-------GN---- 624

  Fly   397 GGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSP-----TGSLQSASPPASASVAAASA 456
                     :...|||...|           :.|..:.:|     ...:....|.|:.||||.:|
Mouse   625 ---------AYALSSPLQLL-----------AAQASSSTPVVITRVCEVGPEEPAAAVSVAANAA 669

  Fly   457 AAAAA 461
            ...||
Mouse   670 PTPAA 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	48/85 (56%)
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269\|PubMed:10620510, ECO:0000269\|PubMed:22476904	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..67
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269\|PubMed:22956541	81..406		67/168 (40%)
		FHA	<88..190	CDD:224630
		FHA	96..189	CDD:238017
		Forkhead	291..377	CDD:278670	48/85 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		1/43 (2%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..719		5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820