DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and Foxd2

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_032619.1	Gene:	Foxd2 / 17301	MGIID:	1347471	Length:	492	Species:	Mus musculus

Alignment Length:	480	Identity:	141/480 - (29%)
Similarity:	190/480 - (39%)	Gaps:	90/480 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPH----QNKEIVKPPYSYIALIAMAIQNA 86
            :|.||.|......||..|         :....|.|.|.    ....:|||||||||||.|||..:
Mouse    90 AAAAAGSPGPGVQAARGA---------TGPGPGPGPPSGGAATRSPLVKPPYSYIALITMAILQS 145

  Fly    87 ADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWTLDPDSY 151
            ..|::||:.|.::|..||||||:....||||||||||||:||||:.|:...||||:||||||:|.
Mouse   146 PKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESA 210

  Fly   152 NMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMTNGILEAKHMAAHAAHFK 216
            :|||||||||||:|||::.:......            ....|..|:..|       ||.|.
Mouse   211 DMFDNGSFLRRRKRFKRQPLPPPHPH------------PHPHPELLLRGG-------AAAAG--- 253

  Fly   217 KEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSLMNVYNPRIHHSAYPYH 281
                 |.|.......::.|             :..|.|:..|.:.........:|..|..|:.:
Mouse   254 -----DPGAFLSSFAAYGA-------------YGYGYGLALPAYGAPPPGPAPHPHPHPHAFAF- 299

  Fly   282 LNEDNLATVASSQMH-HVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHG 345
                  |..|..|:. ....|||...........|..|....|......|.|....|..:....|
Mouse   300 ------AATAPCQLSVPPGRAAAPPPGPPTASVFASAASAPAPAPAPGSGPSPAGLPAFLGAELG 358

  Fly   346 PAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNSSSVLNHNGVGNGGGGGGGGGGGSSSVLTS 410
            .|...:....:||:        .||..       :.|:.|...|:....|||.||||..:.   .
Mouse   359 CAKAFYPASLSPPA--------AGTAA-------SLSTALLRQGLKTDAGGGAGGGGAGTG---Q 405

  Fly   411 SPTSALGFRDMIFEQNQSCQLDTGSPTGS-----LQSASPPASASVAAASAAAAAAVISSH-HHH 469
            .|:.::   |.|...........||..||     ..:|.|...|.|.|...|.|...::.| ...
Mouse   406 RPSFSI---DHIMGHGGGGAAPPGSGDGSPGSPFAAAAGPGGQAQVLAMLTAPALTPVAGHIRLS 467

  Fly   470 HHHHAALSGNLGQLGQLSNLS--HY 492
            |...:.||.......:::.||  |:
Mouse   468 HPGDSLLSSGPSFASKVAGLSGCHF 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	54/85 (64%)
Foxd2	NP_032619.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..125		10/43 (23%)
		Forkhead	129..215	CDD:278670	54/85 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..344		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..441		13/52 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820