Protein Alignment croc and Foxc1

DIOPT Version :10

• Sequence 1: NP_524202.1
• Gene: croc / 40374
• FlyBaseID: FBgn0014143
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_032618.2
• Gene: Foxc1 / 17300
• MGIID: 1347466
• Length: 553
• Species: Mus musculus
• Alignment Length: 515
• Identity: 197/515 - (38%)
• Similarity: 251/515 - (48%)
• Gaps: 100/515 - (19%)

  Fly    22 YGSASAVAAASSASAAAA-----AHYAYDQYSRYPYS-ASAYGLGAPH-QNKEIVKPPYSYIALI 79
            |..|:|.||....:|..|     :|.|:.:  :||.| |.|||...|. |.|::|||||||||||
Mouse    25 YYRAAAAAAGGGYTAMPAPMSVYSHPAHAE--QYPGSMARAYGPYTPQPQPKDMVKPPYSYIALI 87

  Fly    80 AMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYW 144
            .||||||.|||:|||||||:||:|||:|||||||||||||||||||||||||.||||||||||||
Mouse    88 TMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYW 152

  Fly   145 TLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMTNGILEAKHMA 209
            ||||||||||:|||||||||||||||.:::|||..:..      |.|..|.:............|
Mouse   153 TLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLH------LQEPPPPQAGRQPAPAPPEQA 211

  Fly   210 AHAAHFKKEP---LMDLGCLSG------KEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSL 265
            ..:|...:.|   :.|:...:|      :.:|.||.|.|  .|.|.:..     :|.|..:..||
Mouse   212 EGSAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGS--GSAATVPK-----IESPDSSSSSL 269

  Fly   266 MNVYN-PRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAG 329
            .:..: |....||.|..|:       |:........|...||:|...  |.::...|....||:.
Mouse   270 SSGSSPPGSLPSARPLSLD-------AAEPAPPPQPAPPPHHSQGFS--VDNIMTSLRGSPQGSA 325

  Fly   330 GQ-SSGHSPTTISTPHG----PAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNSSSVLNHNG 389
            .: .||...:..::...    |...|.|:|           ||....:.|   .:.|||.    |
Mouse   326 AELGSGLLASAAASSRAGIAPPLALGAYSP-----------GQSSLYSSP---CSQSSSA----G 372

  Fly   390 VGNGGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGS-------------PTGSLQ 441
            ...||||||||||||||...:...:           ...|.|...|             |.|...
Mouse   373 SSGGGGGGGGGGGGSSSAAGTGGAA-----------TYHCNLQAMSLYAAGERGGHLQGPAGGAG 426

  Fly   442 SAS----------PPASASVAAASAAAAAAVISSHHHHHHHHAALSGNLGQLGQLSNLSH 491
            ||:          |||::|.:::.:.......:|||...|.....|..|.|.|  .:|.|
Mouse   427 SAAVDDPLPDYSLPPATSSSSSSLSHGGGGQEASHHPASHQGRLTSWYLNQAG--GDLGH 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	FH_FOX	69..159	CDD:469596	81/89 (91%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q12948	1..51		8/25 (32%)
		FH_FOXC1	73..165	CDD:410818	80/91 (88%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250|UniProtKB:Q12948	78..93		13/14 (93%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250|UniProtKB:Q12948	168..176		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..326		42/174 (24%)
		Required for transcriptional inhibition. /evidence=ECO:0000250|UniProtKB:Q12948	217..366		37/178 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..393		21/43 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..466		11/45 (24%)
		Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q12948	466..553		7/21 (33%)