DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and Foxa2

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001277994.1	Gene:	Foxa2 / 15376	MGIID:	1347476	Length:	465	Species:	Mus musculus

Alignment Length:	388	Identity:	129/388 - (33%)
Similarity:	170/388 - (43%)	Gaps:	98/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AGYGSASAVAAASSASAAAAA------HYAYDQYSRYPYSASAYGLGAPHQNKEIV--------- 69
            ||....:...|..|.||.||.      |.:.........:|.|.|..||:.|...:
Mouse    84 AGMSPGAGAMAGMSGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGL 148

  Fly    70 ----------------KPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSI 118
                            |||||||:||.||||.:.:|.:||:.|||:||:.||:||.|:|.|||||
Mouse   149 SRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSI 213

  Fly   119 RHNLSLNECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKR-- 181
            ||:||.|:||:||.|...||||||:|||.|||.|||:||.:|||::|||     .||:.|:|.
Mouse   214 RHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFK-----CEKQLALKEAA 273

  Fly   182 -----------------QAMMNEKLAEMKPLKLMTNGILEAKHMAAHAAHFKKEPLMDLGCLSGK 229
                             ||.:.|...........|    |:.|.:|......|.     |.||..
Mouse   274 GAASSGGKKTAPGSQASQAQLGEAAGSASETPAGT----ESPHSSASPCQEHKR-----GGLSEL 329

  Fly   230 EVSHAAMLNSCH--DSLAQMNHLAG---GGVEHPGFTVDSLMNVYNPRIHHSAYPYHLNEDNLAT 289
            :.:.|:.|:...  .|..|....|.   |...|||...::.:   .|. ||.|:.:..:.:||
Mouse   330 KGAPASALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHL---KPE-HHYAFNHPFSINNL-- 388

  Fly   290 VASSQMHHVHHAAAAHHAQ------QLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHGP 346
            ::|.|.||..|    ||.|      :....|.|.     |||.|        ||...|...||
Mouse   389 MSSEQQHHHSH----HHHQPHKMDLKAYEQVMHY-----PGGYG--------SPMPGSLAMGP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	57/85 (67%)
Foxa2	NP_001277994.1	Forkhead_N	23..164	CDD:254796	15/79 (19%)
		FH	165..253	CDD:214627	58/87 (67%)
		DUF4799	<224..319	CDD:292674	37/103 (36%)
		HNF_C	381..454	CDD:286443	21/73 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910