DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment croc and Foxc2

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_038547.2	Gene:	Foxc2 / 14234	MGIID:	1347481	Length:	494	Species:	Mus musculus

Alignment Length:	531	Identity:	186/531 - (35%)
Similarity:	236/531 - (44%)	Gaps:	155/531 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLG-----APHQN 65
            |:||     |.:.|..||..::....               ||.:|   ..||.|     ||:.:
Mouse    20 SEQN-----YYRAAGSYGGMASPMGV---------------YSGHP---EQYGAGMGRSYAPYHH 61

  Fly    66 -----KEIVKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLN 125
                 |::|||||||||||.||||||.:||:|||||||:||:|||:||:||||||||||||||||
Mouse    62 QPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLN 126

  Fly   126 ECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNE--- 187
            ||||||.||||||||||||||||||||||:||||||||||||||||.::|||    :|.:.|
Mouse   127 ECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVPKDKEE----RAHLKEPPS 187

  Fly   188 ----------------KLAEMKPLKLMTNGILEAKHMAAHAA---HFKKEPLMDLGCLSGKEVSH 233
                            |.||.|         :..|..||..|   ..|.|.|...|.|.....|.
Mouse   188 TTAKGAPTGTPVADGPKEAEKK---------VVVKSEAASPALPVITKVETLSPEGALQASPRSA 243

  Fly   234 AAM-LNSCHDSLAQMNHLAGGGVEHPGFTVDSLMNV--------YNPRIHHS-------AYPYHL 282
            ::. ..|...||.:.:..|..|:  |||:|:::|.:        .:|....:       |.||..
Mouse   244 SSTPAGSPDGSLPEHHAAAPNGL--PGFSVETIMTLRTSPPGGDLSPAAARAGLVVPPLALPYAA 306

  Fly   283 NEDNLATVASSQMHHVHHAAAAHHAQQLQ--------RHVAHVA-----------HPLTPGGQ-G 327
            ......|...:|  .:..|.:|.:...::        ...|||.           ||..||.. |
Mouse   307 APPAAYTQPCAQ--GLEAAGSAGYQCSMRAMSLYTGAERPAHVCVPPALDEALSDHPSGPGSPLG 369

  Fly   328 AGGQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNSSSVLNHNGVGN 392
            |...::|......::.|...|.|...|:.||..|.|       |..|......:|..|||
Mouse   370 ALNLAAGQEGALGASGHHHQHHGHLHPQAPPPAPQP-------PPAPQPATQATSWYLNH----- 422

  Fly   393 GGGGGGGGGGGSSSVL------TSSPT-----------------SALGFRDMIFEQNQSCQLDTG 434
                     ||..|.|      |...|                 |:||...:   .|.||||...
Mouse   423 ---------GGDLSHLPGHTFATQQQTFPNVREMFNSHRLGLDNSSLGESQV---SNASCQLPYR 475

  Fly   435 SPTGSLQSASP 445
            :.....:.|:|
Mouse   476 ATPSLYRHAAP 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	76/85 (89%)
Foxc2	NP_038547.2	FH	71..159	CDD:214627	77/87 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..213		16/59 (27%)
		EBP50_C	167..>257	CDD:286142	28/102 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..267		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..422		12/47 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849705
Domainoid	1	1.000	174	1.000	Domainoid score	I3661
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3323
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm43746
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4522
SonicParanoid	1	1.000	-	-		X2290
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.890