DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment croc and Foxh1

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_032015.1	Gene:	Foxh1 / 14106	MGIID:	1347465	Length:	401	Species:	Mus musculus

Alignment Length:	463	Identity:	110/463 - (23%)
Similarity:	159/463 - (34%)	Gaps:	148/463 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AAGYGSASAVAAAS-SASAAAAAHYAY-------DQYSRYPYSASAYGLGAPHQNKEIV---KPP 72
            |:|:..||.....: |...|.|....|       |.....|..|.:.......:.|..:   |||
Mouse     2 ASGWDLASTYTPTTPSPQLALAPAQGYLPCMGPRDNSQLRPPEAESLSKTPKRRKKRYLRHDKPP 66

  Fly    73 YSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKK 137
            |:|:|:||:.||.|..:::.|..|.:.:...||::||:.:||::|||||||.|.||.||.:|..|
Mouse    67 YTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFHKVPKDPAK 131

  Fly   138 P-GKGSYWTLD----PDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKL 197
            | .||::|.:|    |.......|.:..||.:.       |....|.
Mouse   132 PQAKGNFWAVDVSLIPAEALRLQNTALCRRWQN-------RGTHRAF------------------ 171

  Fly   198 MTNGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHP---- 258
                   ||.::.:..|                                     |...:.|
Mouse   172 -------AKDLSPYVLH-------------------------------------GQPYQPPSPPP 192

  Fly   259 ----GFTVDSLMNVYNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAH 319
                ||::.||:.  :|. ..|.:|.|......:|.|.                         |.
Mouse   193 PPREGFSIKSLLG--DPG-KESTWPQHPGLPGQSTAAQ-------------------------AG 229

  Fly   320 PLTPG--GQGAGGQSSGHSP--TTISTPHGPAHGGWYTPETPPSEPVPHNGQQGT-PTHPGHNNN 379
            .|:.|  |.|.|..||..:|  ...|.| ||......:.:.....|.|....||: |.|...::.
Mouse   230 TLSKGEEGMGTGPSSSSETPLWPLCSLP-GPTIIEGESSQGEVIRPSPVTPDQGSWPLHLLEDSA 293

  Fly   380 NSSSVLNHNGVGNGGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSPTGSLQSAS 444
            :|..|...              |..:|:....|||.|    .|:..|....|.| .||.|....
Mouse   294 DSRGVPRR--------------GSRASLWGQLPTSYL----PIYTPNVVMPLAT-LPTTSCPQC- 338

  Fly   445 PPASASVA 452
             |:|||.|
Mouse   339 -PSSASPA 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	39/90 (43%)
Foxh1	NP_032015.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		3/24 (13%)
		FH	64..142	CDD:238016	37/77 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..251		22/136 (16%)
		SMAD-interaction domain (SID)	307..390		16/46 (35%)
		Fast/FoxH1 motif 1 (FM1)	311..315		2/3 (67%)
		Fast/FoxH1 motif 2 (FM2)	321..327		1/5 (20%)
		SMAD interaction motif (SIM)	363..384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820