DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment croc and foxc1a

DIOPT Version :9

Sequence 1:	NP_524202.1	Gene:	croc / 40374	FlyBaseID:	FBgn0014143	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_571803.1	Gene:	foxc1a / 100148408	ZFINID:	ZDB-GENE-010302-1	Length:	476	Species:	Danio rerio

Alignment Length:	516	Identity:	184/516 - (35%)
Similarity:	240/516 - (46%)	Gaps:	132/516 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYAYDQYSRYPYS-ASAYGLGAPH-QNKEI 68
            |||:     |.:.|||.|.....|..:..|     |.|:||   ||.| |.|||...|. |.|::
Zfish    21 SDQS-----YYRAAAGGGYTGMPAPMTMYS-----HAAHDQ---YPASMARAYGPYTPQPQPKDM 72

  Fly    69 VKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVAR 133
            |||||||||||.|||||:.|||||||||||:||||||:|||||||||||||||||||||||||.|
Zfish    73 VKPPYSYIALITMAIQNSPDKKVTLNGIYQFIMERFPFYRDNKQGWQNSIRHNLSLNECFVKVPR 137

  Fly   134 DDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKE-----EAIKRQAMMNEKLAEM- 192
            |||||||||||||||||||||:|||||||||||||||.|::||     ||..|||....:..|.
Zfish   138 DDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAMKDKEDRGVKEAPSRQAQPQAREQEQS 202

  Fly   193 ----KPLKLMTNGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCH----------DS 243
                :|:::..   ::.::..:.........|..:..:...:.|.:....|.|          ||
Zfish   203 VPGSQPVRIQD---IKTENGTSTPPQAVSPTLSTVPKIESPDSSSSMSSGSPHSIPSTRSLSLDS 264

  Fly   244 LAQMNHLAGGGVEHPGFTVDSLMNV------------------------------YNPRIHHSAY 278
            ..:.:|.|..    .||:||::|..                              |:|. ..|.|
Zfish   265 AGEQHHQAPA----QGFSVDNIMTSLRGSPHSSGELTPSLVAPSRTGITPTLSLNYSPN-QSSVY 324

  Fly   279 PYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTP 343
            ....::::::|.:::..|....|.:.:                      |||..|||..||.:|
Zfish   325 SSPCSQNSISTTSNATYHCNMQAMSLY----------------------AGGDRSGHLGTTATT- 366

  Fly   344 HGPAHGGWYTPETPP-------SEPVPH----NGQQGTPTHPGHNNNNSSSVLNHNG-VGNGGGG 396
                     ..||.|       :..:.|    :.|:|   |..|....:|..||..| :|:.|..
Zfish   367 ---------VDETLPDYSITTTTSSLSHGNLSSAQEG---HHPHQGRLASWYLNQAGDIGHLGAT 419

  Fly   397 GGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSPTGSLQSASPPASASVAAASAA 457
            .........||.....:..:|..:.....|.|||:            |.|.|..:...|.|
Zfish   420 YPAQQQNFHSVREMFESQRIGLNNSPVNGNNSCQM------------SFPPSQPIYRTSGA 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
croc	NP_524202.1	Forkhead	70..156	CDD:278670	79/85 (93%)
foxc1a	NP_571803.1	Forkhead	74..160	CDD:278670	79/85 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..271		22/104 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..303		0/18 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3591
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3317
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm26006
orthoMCL	1	0.900	-	-		OOG6_109214
Panther	1	1.100	-	-	LDO	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4522
SonicParanoid	1	1.000	-	-		X2290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860