DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx6 and STX10

DIOPT Version :9

Sequence 1:	NP_995816.1	Gene:	Syx6 / 40373	FlyBaseID:	FBgn0037084	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_003756.1	Gene:	STX10 / 8677	HGNCID:	11428	Length:	249	Species:	Homo sapiens

Alignment Length:	322	Identity:	116/322 - (36%)
Similarity:	157/322 - (48%)	Gaps:	84/322 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PF--PNSEVFKALNKTRGLYLRWRELGEN----GGTEAEWTTTELRNSLRSIEWDLEDLEDTISI 82
            ||  ...||.||:|..||||.||.||.:.    |..|.:|||.||||.||||||||||||:||.|
Human     6 PFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGI 70

  Fly    83 VEKNPSKFRIDNRELSSRRHFIDNTRDEVKQMKDKMSLNRSRDRDITAHQPLLDNDRHSPNHNHS 147
            ||.||.||::...:|..|:.|::..|:.|::|||.|.                     ||.   :
Human    71 VEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMV---------------------SPT---A 111

  Fly   148 IAIPNSNSNSNEYHQHPHNDRTYLVECPNGNSLINSGSQVANTIAGTMSAAAAAASRHSGTKYSK 212
            :|....|                       |..|.:|...|......:..|:|.
Human   112 VAFLERN-----------------------NREILAGKPAAQKSPSDLLDASAV----------- 142

  Fly   213 LENALDSPSHYGQTHHGGMDSPSHRYVGETVSIQQRMIQGQDEQLDMISDSIGTLKTVSRQIGVE 277
                                |.:.||:.|..:.||.::..||:||:|:|.||..||.:|.::|.|
Human   143 --------------------SATSRYIEEQQATQQLIMDEQDQQLEMVSGSIQVLKHMSGRVGEE 187

  Fly   278 LDEQAVMLDDFGNEFDTTESKLDTTMKKVAKVLHMNNDKRQWAAILILSGLLLFVIILFIIL 339
            ||||.:|||.|..|.|.|:|::|..::|:|||.||.:|:|||.||.:|.|:||.|:||...|
Human   188 LDEQGIMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSDRRQWCAIAVLVGVLLLVLILLFSL 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx6	NP_995816.1	Syntaxin-6_N	29..115	CDD:286286	48/89 (54%)
Syx6	NP_995816.1	SNARE_Syntaxin6	250..315	CDD:277204	32/64 (50%)
STX10	NP_003756.1	Syntaxin-6_N	13..103	CDD:286286	48/89 (54%)
STX10	NP_003756.1	SNARE_Syntaxin6	160..225	CDD:277204	32/64 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154219
Domainoid	1	1.000	104	1.000	Domainoid score	I6700
eggNOG	1	0.900	-	-		E1_KOG3202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3650
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53942
OrthoDB	1	1.010	-	-		D1563292at2759
OrthoFinder	1	1.000	-	-		FOG0003084
OrthoInspector	1	1.000	-	-		otm42236
orthoMCL	1	0.900	-	-		OOG6_101619
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1528
SonicParanoid	1	1.000	-	-		X3993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800