Protein Alignment Syx6 and STX10

DIOPT Version :10

• Sequence 1: NP_995816.1
• Gene: Syx6 / 40373
• FlyBaseID: FBgn0037084
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_003756.1
• Gene: STX10 / 8677
• HGNCID: 11428
• Length: 249
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 116/322 - (36%)
• Similarity: 157/322 - (48%)
• Gaps: 84/322 - (26%)

  Fly    24 PF--PNSEVFKALNKTRGLYLRWRELGEN----GGTEAEWTTTELRNSLRSIEWDLEDLEDTISI 82
            ||  ...||.||:|..||||.||.||.:.    |..|.:|||.||||.||||||||||||:||.|
Human     6 PFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGI 70

  Fly    83 VEKNPSKFRIDNRELSSRRHFIDNTRDEVKQMKDKMSLNRSRDRDITAHQPLLDNDRHSPNHNHS 147
            ||.||.||::...:|..|:.|::..|:.|::|||.|.                     ||.   :
Human    71 VEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMV---------------------SPT---A 111

  Fly   148 IAIPNSNSNSNEYHQHPHNDRTYLVECPNGNSLINSGSQVANTIAGTMSAAAAAASRHSGTKYSK 212
            :|....|                       |..|.:|...|......:..|:|.
Human   112 VAFLERN-----------------------NREILAGKPAAQKSPSDLLDASAV----------- 142

  Fly   213 LENALDSPSHYGQTHHGGMDSPSHRYVGETVSIQQRMIQGQDEQLDMISDSIGTLKTVSRQIGVE 277
                                |.:.||:.|..:.||.::..||:||:|:|.||..||.:|.::|.|
Human   143 --------------------SATSRYIEEQQATQQLIMDEQDQQLEMVSGSIQVLKHMSGRVGEE 187

  Fly   278 LDEQAVMLDDFGNEFDTTESKLDTTMKKVAKVLHMNNDKRQWAAILILSGLLLFVIILFIIL 339
            ||||.:|||.|..|.|.|:|::|..::|:|||.||.:|:|||.||.:|.|:||.|:||...|
Human   188 LDEQGIMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSDRRQWCAIAVLVGVLLLVLILLFSL 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx6	NP_995816.1	SNARE_NTD_STX6_STX10	24..119	CDD:410569	53/100 (53%)
		SNARE_Syntaxin6	250..315	CDD:277204	32/64 (50%)
STX10	NP_003756.1	SNARE_NTD_STX10	5..107	CDD:410572	53/100 (53%)
		SNARE_Syntaxin6	160..225	CDD:277204	32/64 (50%)