DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx6 and stx6

DIOPT Version :9

Sequence 1:	NP_995816.1	Gene:	Syx6 / 40373	FlyBaseID:	FBgn0037084	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001017879.1	Gene:	stx6 / 550577	ZFINID:	ZDB-GENE-030131-858	Length:	256	Species:	Danio rerio

Alignment Length:	322	Identity:	129/322 - (40%)
Similarity:	177/322 - (54%)	Gaps:	77/322 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PF--PNSEVFKALNKTRGLYLRWRELGENGG----TEAEWTTTELRNSLRSIEWDLEDLEDTISI 82
            ||  ...||.||:|..:||:.||.||.::.|    .|.:|||.||||||||||||||||::||||
Zfish     6 PFFVVKGEVQKAVNTAQGLHQRWIELLQDAGGASKEEVDWTTNELRNSLRSIEWDLEDLDETISI 70

  Fly    83 VEKNPSKFRIDNRELSSRRHFIDNTRDEVKQMKDKMSLNRSRDRDITAHQPLLDNDRHSPNHNHS 147
            ||.||.||.:|..||:.|:.||.:||..|::|||.|:                     ||   .:
Zfish    71 VEANPKKFNLDAMELAKRKAFITSTRQTVREMKDHMT---------------------SP---MA 111

  Fly   148 IAIPNSNSNSNEYHQHPHNDRTYLVECPNGNSLINSGSQVANTIAGTMSAAAAAASRHSGTKYSK 212
            |.:|                     |..|..:|:..|            .:.....:.||.||::
Zfish   112 ITVP---------------------EKKNRQTLMGEG------------GSRGPIWQPSGEKYTR 143

  Fly   213 LENALDSPSHYGQTHHGGMDSPSHRYVGETVSIQQRMIQGQDEQLDMISDSIGTLKTVSRQIGVE 277
            |:|.|              .:.:.:::.|..:.||.:.:.|||.|:::|.:||.||.:|::||.|
Zfish   144 LDNEL--------------QTANSQFIEEQQTQQQLIAEKQDEHLELVSGTIGVLKNMSQRIGQE 194

  Fly   278 LDEQAVMLDDFGNEFDTTESKLDTTMKKVAKVLHMNNDKRQWAAILILSGLLLFVIILFIIL 339
            |||||||||||.:|.|:|:|:||..|||:|||.||.:|||||.||.:|..:|..||:|||||
Zfish   195 LDEQAVMLDDFSHEMDSTQSRLDNVMKKLAKVSHMTSDKRQWCAIGVLLAILFVVILLFIIL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx6	NP_995816.1	Syntaxin-6_N	29..115	CDD:286286	51/89 (57%)
Syx6	NP_995816.1	SNARE_Syntaxin6	250..315	CDD:277204	38/64 (59%)
stx6	NP_001017879.1	Syntaxin-6_N	13..103	CDD:286286	51/89 (57%)
stx6	NP_001017879.1	SNARE_Syntaxin6	168..232	CDD:277204	38/63 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589424
Domainoid	1	1.000	101	1.000	Domainoid score	I6893
eggNOG	1	0.900	-	-		E1_KOG3202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H115622
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3707
OMA	1	1.010	-	-		QHG53942
OrthoDB	1	1.010	-	-		D1563292at2759
OrthoFinder	1	1.000	-	-		FOG0003084
OrthoInspector	1	1.000	-	-		otm25128
orthoMCL	1	0.900	-	-		OOG6_101619
Panther	1	1.100	-	-	O	PTHR19957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1528
SonicParanoid	1	1.000	-	-		X3993
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800