DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx6 and tlg1

DIOPT Version :9

Sequence 1:	NP_995816.1	Gene:	Syx6 / 40373	FlyBaseID:	FBgn0037084	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_595989.1	Gene:	tlg1 / 2540973	PomBaseID:	SPBC36B7.07	Length:	225	Species:	Schizosaccharomyces pombe

Alignment Length:	318	Identity:	71/318 - (22%)
Similarity:	118/318 - (37%)	Gaps:	98/318 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PF--PNSEVFKALNKTRGLYLRWRELGENGGTEAEWTTTELRNSLRSIEWDLEDLEDTISIVEKN 86
            ||  ..::....:.:.|.||..:. ...|.|..:  ..|||..::..:...|:||:..:.|..||
pombe     4 PFYEVKADASNQMEQVRKLYNSFM-AARNSGVLS--PNTELTYAIDELSETLKDLKAAVEIAMKN 65

  Fly    87 PSKFRIDNRELSSRRHFIDNTRDEVKQMKDKMSLNRSRDRDITAHQPLLDNDRHSPNHNHSIAIP 151
            ...|.:|..||.|||.|:.....|:..::.||.                             |.|
pombe    66 SEHFGLDEEELKSRRRFVSELDIELNNIQLKMG-----------------------------AAP 101

  Fly   152 NSNSNSNEYHQHPHNDRTYLVECPNGNSLINSGSQVANTIAGTMSAAAAAASRHSGTKYSKLENA 216
            ::          |.:...|.|:  ||.|            ||
pombe   102 ST----------PVSTEPYTVD--NGAS------------AG----------------------- 119

  Fly   217 LDSPSHYGQTHHGGMDSPSHRYVGETVSIQQRMIQGQDEQLDMISDSIGTLKTVSRQIGVELDEQ 281
            |....|          :.:.:|       |:::.|.||..||.:.|:||.::..:..:|.||.:|
pombe   120 LSEEDH----------AVNRQY-------QEQLYQQQDVMLDGVYDTIGNIRGQAALMGEELGQQ 167

  Fly   282 AVMLDDFGNEFDTTESKLDTTMKKVAKVLHMNNDKRQWAAILILSGLLLFVIILFIIL 339
            |.:||...|..:||.|||...||::......:.|.:....|.:|..:|:.:::|.|:|
pombe   168 ADLLDTLDNSIETTNSKLRRGMKRLKDFTIASADSKSGCCITVLIIILIALLVLVIVL 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx6	NP_995816.1	Syntaxin-6_N	29..115	CDD:286286	23/85 (27%)
Syx6	NP_995816.1	SNARE_Syntaxin6	250..315	CDD:277204	23/64 (36%)
tlg1	NP_595989.1	Syntaxin-6_N	11..94	CDD:286286	23/85 (27%)
tlg1	NP_595989.1	SNARE_Syntaxin6	140..201	CDD:277204	21/60 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H115622
Inparanoid	1	1.050	98	1.000	Inparanoid score	I1679
OMA	1	1.010	-	-		QHG53942
OrthoFinder	1	1.000	-	-		FOG0003084
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101619
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1528
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860