Protein Alignment Syx6 and STX6

DIOPT Version :10

• Sequence 1: NP_995816.1
• Gene: Syx6 / 40373
• FlyBaseID: FBgn0037084
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_005810.1
• Gene: STX6 / 10228
• HGNCID: 11441
• Length: 255
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 131/323 - (40%)
• Similarity: 179/323 - (55%)
• Gaps: 80/323 - (24%)

  Fly    24 PF--PNSEVFKALNKTRGLYLRWRELGENGGT----EAEWTTTELRNSLRSIEWDLEDLEDTISI 82
            ||  ...||.||:|..:||:.||.||.::..|    |.:|||.||||:|||||||||||::||||
Human     6 PFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLEDLDETISI 70

  Fly    83 VEKNPSKFRIDNRELSSRRHFIDNTRDEVKQMKDKMSLNRSRDRDITAHQPLLDNDRHSPNHNHS 147
            ||.||.||.:|..|||.|:.||.:||..|:.|||:||.:     .:.|
Human    71 VEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTS-----SVQA----------------- 113

  Fly   148 IAIPNSNSNSNEYHQHPHNDRTYLVECPNGNSLI-NSGSQVANTIAGTMSAAAAAASRHSGTKYS 211
                                   |.|..|..:|: :||||  |...||..            ||.
Human   114 -----------------------LAERKNRQALLGDSGSQ--NWSTGTTD------------KYG 141

  Fly   212 KLENALDSPSHYGQTHHGGMDSPSHRYVGETVSIQQRMIQGQDEQLDMISDSIGTLKTVSRQIGV 276
            :|:..|...:             || ::.|..:.||.:::.|||||:::|.|||.||.:|::||.
Human   142 RLDRELQRAN-------------SH-FIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGG 192

  Fly   277 ELDEQAVMLDDFGNEFDTTESKLDTTMKKVAKVLHMNNDKRQWAAILILSGLLLFVIILFIIL 339
            ||:||||||:||.:|.::|:|:||..|||:|||.||.:|:|||.||.||..:||.|:|||::|
Human   193 ELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLILFLVL 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx6	NP_995816.1	SNARE_NTD_STX6_STX10	24..119	CDD:410569	56/100 (56%)
		SNARE_Syntaxin6	250..315	CDD:277204	37/64 (58%)
STX6	NP_005810.1	Required for interaction with VPS51. /evidence=ECO:0000250|UniProtKB:Q63635	2..168		79/234 (34%)
		SNARE_NTD_STX6	5..107	CDD:410573	56/100 (56%)
		SNARE_Syntaxin6	166..231	CDD:277204	37/64 (58%)