DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx6 and stx10

DIOPT Version :9

Sequence 1:	NP_995816.1	Gene:	Syx6 / 40373	FlyBaseID:	FBgn0037084	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001313376.1	Gene:	stx10 / 100151249	ZFINID:	ZDB-GENE-041111-53	Length:	247	Species:	Danio rerio

Alignment Length:	322	Identity:	114/322 - (35%)
Similarity:	161/322 - (50%)	Gaps:	86/322 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PF--PNSEVFKALNKTRGLYLRWRELGEN----GGTEAEWTTTELRNSLRSIEWDLEDLEDTISI 82
            ||  ...||.|||:|.:|||.||.||.:.    ...|.:|:|.||||.||:|:||||||.:||||
Zfish     6 PFFVVKGEVQKALSKAQGLYERWEELLQEETPVSRDELDWSTNELRNCLRAIDWDLEDLHETISI 70

  Fly    83 VEKNPSKFRIDNRELSSRRHFIDNTRDEVKQMKDKMSLNRSRDRDITAHQPLLDNDRHSPNHNHS 147
            ||.||.|||:...||..||.|::.||..|:.||:::|                     ||:
Zfish    71 VEANPGKFRLGEHELQERRDFVERTRKSVQLMKEQLS---------------------SPS---- 110

  Fly   148 IAIPNSNSNSNEYHQHPHNDRTYLVECPNGNSLINSGSQVANTIAGTMSAAAAAASRHSGTKYSK 212
             |:..:                   |..|..:|:                .|.|..|::|.
Zfish   111 -AVAQA-------------------EKKNKQALL----------------GATAKDRYAGL---- 135

  Fly   213 LENALDSPSHYGQTHHGGMDSPSHRYVGETVSIQQRMIQGQDEQLDMISDSIGTLKTVSRQIGVE 277
                        :.|   :.|.:.||:.|....||.::|.|||.|::::.||..||.:|.:||.|
Zfish   136 ------------EPH---LVSANSRYIQEQQEQQQLIMQDQDEHLELVTGSIRVLKDMSSRIGDE 185

  Fly   278 LDEQAVMLDDFGNEFDTTESKLDTTMKKVAKVLHMNNDKRQWAAILILSGLLLFVIILFIIL 339
            ||||||||.:|..|.|.|.|::|:.:||:.||.||.:.:|||.||.:|..:|:.|:|||..:
Zfish   186 LDEQAVMLGEFNEEMDQTGSRMDSVLKKMEKVSHMTSSRRQWCAIGVLVIILIVVLILFFAI 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx6	NP_995816.1	Syntaxin-6_N	29..115	CDD:286286	48/89 (54%)
Syx6	NP_995816.1	SNARE_Syntaxin6	250..315	CDD:277204	33/64 (52%)
stx10	NP_001313376.1	Syntaxin-6_N	13..103	CDD:312631	48/89 (54%)
stx10	NP_001313376.1	SNARE_Syntaxin6	158..222	CDD:277204	33/63 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589422
Domainoid	1	1.000	101	1.000	Domainoid score	I6893
eggNOG	1	0.900	-	-		E1_KOG3202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3707
OMA	1	1.010	-	-		QHG53942
OrthoDB	1	1.010	-	-		D1563292at2759
OrthoFinder	1	1.000	-	-		FOG0003084
OrthoInspector	1	1.000	-	-		otm25128
orthoMCL	1	0.900	-	-		OOG6_101619
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1528
SonicParanoid	1	1.000	-	-		X3993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800