DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp1 and alpl

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_957301.2	Gene:	alpl / 393982	ZFINID:	ZDB-GENE-040420-1	Length:	561	Species:	Danio rerio

Alignment Length:	506	Identity:	220/506 - (43%)
Similarity:	297/506 - (58%)	Gaps:	39/506 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PEQSWDLDSISELKSKEFWFHDAQRTLYNKLSTPP-NQYRAKNVIFFLGDGMSVPTVTAGRIFDG 88
            |||.         |..::|...|||:|.:.|.... |:..|||:|.||||||.||||||.||..|
Zfish    57 PEQE---------KRPDYWRDFAQRSLKDALKLQELNKNIAKNIILFLGDGMGVPTVTAARILKG 112

  Fly    89 QLRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCR 153
            ||.|..||..:||.:||.:|.|||||..|.||.|||.||:|:|.|:|||..|:||:|....:.|.
Zfish   113 QLSGQNGEETQLEMDKFPHVALSKTYNTNAQVPDSAGTATAFLCGVKANEGTVGVSAAAVRSQCN 177

  Fly   154 GSRLPQNRLSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCP 218
            .::  .|.::||..||....||.|:||||||.||:|:..|||..:||:.||.|:.......| |.
Zfish   178 TTQ--GNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDADMPNEALQSG-CK 239

  Fly   219 DIAQQLIDG--DVGKRLRVVMGGGTIKFLPNTTNDVF--GNK---GQRLDNRNLIEEW-QQTKPG 275
            |||:||.:.  |:    .|:||||.....|..|.||.  |:|   |.|.|.|||:.|| .:.|..
Zfish   240 DIARQLFENIPDI----NVIMGGGRRSMYPKNTPDVEYPGDKKQNGTRKDGRNLVGEWIDRVKEK 300

  Fly   276 NARVVFSRTDLLNNDAQNTDFLLGLFNASHLAYHMDDSIDT-PTLPEMTAAAINVLSRDPNGYFL 339
            ....|:::.|||:.:..|.|:|||||..:.|.|.::.:.:. |:|.||...||.:|.::..|:||
Zfish   301 RGFYVWNKKDLLSLNPNNVDYLLGLFEPADLNYELERNTENDPSLTEMVDVAIKILKKNERGFFL 365

  Fly   340 FVEGGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNS 404
            .||||||||.|||.|||:||.|.|:...|:.:|..||:.:|||.||:|||.|..:..||....||
Zfish   366 LVEGGRIDHGHHEGKAKQALHEAVEMDRAITRAGLLTSEYDTLTVVTADHSHVFSFGGYTPRGNS 430

  Fly   405 IVGLNSELSNVDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEET 469
            |.||...||:|||.|:|:|.|.|||.    :|..:|..|.|.  .:|:.:.:......||:..||
Zfish   431 IFGLAPTLSDVDQKPFTAILYGNGPG----FKLVNGARENVS--TVDYQQNNYQAQSAVPLRMET 489

  Fly   470 HGGGDVAVYAHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYC 520
            |||.|||:::       :||.:||..||.||..:||:|.:|:|:|....:|
Zfish   490 HGGEDVAIFS-------KGPMAHLLHGVQEQHYIPHVMAYAACIGQNKDHC 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	206/457 (45%)
alpl	NP_957301.2	Alk_phosphatase	88..526	CDD:278666	206/457 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593263
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R959
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840