DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp1 and SPBC14F5.13c

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_596739.1	Gene:	SPBC14F5.13c / 2539926	PomBaseID:	SPBC14F5.13c	Length:	532	Species:	Schizosaccharomyces pombe

Alignment Length:	533	Identity:	134/533 - (25%)
Similarity:	218/533 - (40%)	Gaps:	115/533 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRLEFEKFN 106
            |:|..:.:      |...|: :.|.||..:.|||...:::..|.|...|....|.|..|:   .:
pombe    44 FYFFSSHK------SKGTNE-KPKFVIMMVSDGMGPGSLSMTRSFVETLNDKEGYRLPLD---EH 98

  Fly   107 YVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSIAAWALK 171
            .:|.|:|...:..:.|||..|:|:....|.....:||..:            :....:|...|.:
pombe    99 LIGSSRTRSSSSLITDSAAGATAFSCANKTYNGAVGVLDN------------EKPCGTILEAAKE 151

  Fly   172 GSKSAGLVTTTRVTHASPAGVYAHTSNR---DFESDYDVTKLGQNPGNCPDIAQQLIDGDVGKRL 233
            .....|:|.|:|||.|:||...||.:||   |..::|.|   |..|              :|:.:
pombe   152 AGYLTGIVVTSRVTDATPASFSAHAANRFMQDLIAEYQV---GMGP--------------LGRSV 199

  Fly   234 RVVMGGGTIKFLPNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLLNNDAQNTDF-L 297
            .::.|||...|||.:|     .:..|.||.:|: ::.:.|.| .:::.:|||.  ::..|... |
pombe   200 DLLFGGGLCSFLPKST-----YRSCRSDNLDLL-KYARKKEG-FQILLNRTDF--DELSNAQLPL 255

  Fly   298 LGLFNASHLAYHMDDSIDT-PTLPEMTAAAINVLSRDPN-----GYFLFVEGGRIDHAHHETKAK 356
            ||||:..||:|.:|...:. |.|.||...|::||....|     |:||.:||.|||.|.|.....
pombe   256 LGLFSDYHLSYDIDYQPEVQPKLSEMVETALDVLLNATNEDTSKGFFLLIEGSRIDMASHNNDPI 320

  Fly   357 KALDETVQFSDAVRKARQLTNPWDTLIVVSADH---GHTV---TISGYPD----------VNNSI 405
            ..:.|.::::.|...|..........::.::||   |.||   ....||:          ..:||
pombe   321 AHVYEVMEYNRAFEIASAFVEKNGGSLISTSDHETGGLTVGRQVSKKYPEYLWKPQVLSLALHSI 385

  Fly   406 VGLNSELSNVDQ---LPYTSISYANGPAYERFYKSTDGV------------VERVDLRNLDFSKP 455
            ..|.|.:.|.:|   |||          .|:|.....|:            |.|.::.||.....
pombe   386 EYLASAIVNHNQNTLLPY----------IEQFVLPAIGIPDPNPKQIHDIYVARHNIFNLINVLS 440

  Fly   456 DAIYPHG-VPMTEETHGGGDVAVY--AHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGI 517
            |.:.... :..|...|...||.||  ..|.|: |:|...::..|.:.:..|            .:
pombe   441 DIVSVEAQIGWTTHGHTAVDVNVYGVGEVTEH-LRGNMENIEIGQFMEIYL------------NV 492

  Fly   518 TYCDLQPKARYSP 530
            :..|:..|.:.:|
pombe   493 SLSDVTEKLKDAP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	127/492 (26%)
SPBC14F5.13c	NP_596739.1	PhoA	3..495	CDD:224699	131/521 (25%)
SPBC14F5.13c	NP_596739.1	ALP_like	60..487	CDD:304875	126/478 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	124	1.000	Domainoid score	I1405
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I1462
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm46986
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R959
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	11	10.890