DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp1 and ALPP

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001623.3	Gene:	ALPP / 250	HGNCID:	439	Length:	535	Species:	Homo sapiens

Alignment Length:	502	Identity:	223/502 - (44%)
Similarity:	295/502 - (58%)	Gaps:	37/502 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRL 100
            |.::.:||..:|...|.......|.|..|||:|.||||||.|.||||.||..||.:..:|....|
Human    27 EEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPL 91

  Fly   101 EFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSI 165
            ..::|.||.|||||.|:|.|.||..||:|||.|:|.|:.|||::|....|.|..:|  .|.:.|:
Human    92 AMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISV 154

  Fly   166 AAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDG-DV 229
            ...|.|..||.|:||||||.||||||.||||.||::.||.||....:..| |.|||.|||.. |:
Human   155 MNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEG-CQDIATQLISNMDI 218

  Fly   230 GKRLRVVMGGGTIKFL-------PNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLL 287
            .    |::|||. |::       |...:| :...|.|||.:||::||...:.| ||.|::||:|:
Human   219 D----VILGGGR-KYMFRMGTPDPEYPDD-YSQGGTRLDGKNLVQEWLAKRQG-ARYVWNRTELM 276

  Fly   288 NNDAQ-NTDFLLGLFNASHLAY--HMDDSIDTPTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHA 349
            ..... :...|:|||....:.|  |.|.::| |:|.|||.||:.:|||:|.|:|||||||||||.
Human   277 QASLDPSVTHLMGLFEPGDMKYEIHRDSTLD-PSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHG 340

  Fly   350 HHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSN 414
            |||::|.:||.||:.|.||:.:|.|||:..|||.:|:|||.|..:..|||...:||.||....:.
Human   341 HHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKAR 405

  Fly   415 VDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYA 479
             |:..||.:.|.|||.    |...||.  |.|:...:...|:......||:.||||.|.||||:|
Human   406 -DRKAYTVLLYGNGPG----YVLKDGA--RPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFA 463

  Fly   480 HVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKA 526
                   :||.:||..||.||:.:.|:|.||:||.| .|.|||.|.|
Human   464 -------RGPQAHLVHGVQEQTFIAHVMAFAACLEP-YTACDLAPPA 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	207/459 (45%)
ALPP	NP_001623.3	PRK10518	28..478	CDD:236706	208/474 (44%)
		Alk_phosphatase	55..490	CDD:278666	207/459 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..449		6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157494
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R959
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840