Protein Alignment Alp1 and ALPI

DIOPT Version :9

• Sequence 1: NP_001262159.1
• Gene: Alp1 / 40372
• FlyBaseID: FBgn0283479
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 226/501 - (45%)
• Similarity: 291/501 - (58%)
• Gaps: 33/501 - (6%)

  Fly    35 SELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNR 99
            :|.::..||...|...|.......|.|..|||:|.|||||:.||||||.||..||..|.:|....
Human    23 AEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETP 87

  Fly   100 LEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSS 164
            |..::|.|:.|||||.|::||.|||.||:|||.|:|||:.|||::|....|.|..:|  .|.:.|
Human    88 LAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTR--GNEVIS 150

  Fly   165 IAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDG-D 228
            :...|.:..||.|:||||||.||||||.||||.||::.||.|:....:..| |.|||.|||.. |
Human   151 VMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEG-CQDIATQLISNMD 214

  Fly   229 VGKRLRVVMGGGTIKFLPNTTNDV-----FGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLLN 288
            :.    |::|||.....|..|.|.     ....|.|||.:||::||.....| |..|::||:|:.
Human   215 ID----VILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQG-AWYVWNRTELMQ 274

  Fly   289 NDA-QNTDFLLGLFNASHLAY--HMDDSIDTPTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHAH 350
            ... |:...|:|||......|  |.|.::| |:|.|||.||:.:|||:|.|::||||||||||.|
Human   275 ASLDQSVTHLMGLFEPGDTKYEIHRDPTLD-PSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGH 338

  Fly   351 HETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSNV 415
            ||..|.:||.|.|.|.||:.:|.|||:..|||.:|:|||.|..:..||....:||.||....:.
Human   339 HEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQ- 402

  Fly   416 DQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYAH 480
            |...||||.|.|||.|  .:.|  ||  |.|:...:...||......||::.|||||.||||:|
Human   403 DSKAYTSILYGNGPGY--VFNS--GV--RPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFA- 460

  Fly   481 VVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKA 526
                  :||.:||..||.|||.:.|:|.||:||.| .|.|||.|.|
Human   461 ------RGPQAHLVHGVQEQSFVAHVMAFAACLEP-YTACDLAPPA 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	210/457 (46%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	210/457 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157468
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.810