DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp1 and Alpi

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_073156.3	Gene:	Alpi / 24197	RGDID:	2099	Length:	540	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	222/503 - (44%)
Similarity:	279/503 - (55%)	Gaps:	39/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRL 100
            |.::..||...|:..|.......|.|..|||:|.||||||.||||||.||..|||.|.:|....|
  Rat    25 EEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPL 89

  Fly   101 EFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSI 165
            ..:.|.:..|||||.|::||.|||.||:|||.|:||||.||||:|....|.|..:.  .|.:.|:
  Rat    90 AMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTF--GNEVFSV 152

  Fly   166 AAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDG-DV 229
            ...|.|..||.|:||||||.||||||.||||.|||:.||.|:.......| |.|||.|||.. |:
  Rat   153 MHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEG-CKDIATQLISNMDI 216

  Fly   230 GKRLRVVMGGGTIKFLPNTTNDV-----FGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLL-- 287
            .    |::|||.....|..|.|.     ....|.|||:|||:|||.....| .|.|::|..|:
  Rat   217 D----VILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQG-TRYVWNREQLMQA 276

  Fly   288 NNDAQNTDFLLGLFNASHLAYHMDDSIDT-PTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHAHH 351
            :.|...|. |:|||..:.:.|.::.:... |:|.|||..|:.:|||:|.|::|||||||||..||
  Rat   277 SQDPAVTR-LMGLFEPAEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHH 340

  Fly   352 ETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSNVD 416
            ...|..||.|.|.|..|:.||.||||..|||.:::|||.|.....||.....||.|| :.|:..|
  Rat   341 AGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGL-APLNAQD 404

  Fly   417 QLPYTSISYANGPAYERFYKSTDGVVERVDLRNL-DFSKPDAIYPH--GVPMTEETHGGGDVAVY 478
            ...||||.|.|||.|         |:...:..|: |....|..|..  .||::.|||||.|||::
  Rat   405 GKSYTSILYGNGPGY---------VLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIF 460

  Fly   479 AHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKA 526
            |       :||.:||..||.||:.:.|:|.||.||.| .|.|.|.|.|
  Rat   461 A-------RGPQAHLVHGVQEQNYIAHVMAFAGCLEP-YTDCGLAPPA 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	207/460 (45%)
Alpi	NP_073156.3	Alk_phosphatase	53..488	CDD:278666	207/460 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351451
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.760