DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp1 and Alppl2

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_031459.3	Gene:	Alppl2 / 11650	MGIID:	108009	Length:	529	Species:	Mus musculus

Alignment Length:	529	Identity:	213/529 - (40%)
Similarity:	283/529 - (53%)	Gaps:	45/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LALQLTACSSQYKYGPEQSWDLDSISELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDG 74
            |.|.|..|.|....            |.::..||...|...|.......|.|..|||::..:|||
Mouse     9 LGLSLQVCPSVIPV------------EEENPAFWNRKAAEALDAAKKLKPIQTSAKNLVILMGDG 61

  Fly    75 MSVPTVTAGRIFDGQLRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYL 139
            |.|.||||.||..||.:|.:|...:|..::|.::.|||||..:||:.|||.|.:|:|.|:|.|..
Mouse    62 MGVSTVTATRILKGQQQGHLGPETQLAMDRFPHMALSKTYNTDKQIPDSAGTGTAFLCGVKTNMK 126

  Fly   140 TIGVTADVELNDCRGSRLPQNRLSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESD 204
            .||::|....|.|..:.  .|.:.|:...|.|..||.|:||||.|.||||||.||||.||.:.||
Mouse   127 VIGLSAAARFNQCNTTW--GNEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRGWYSD 189

  Fly   205 YDVTKLGQNPGNCPDIAQQLIDG-DVGKRLRVVMGGGTIKFLPNTTNDV-----FGNKGQRLDNR 263
            ..:.......| |.||:.|||.. |:.    |::|||.....|..|.|.     ....|.|||.|
Mouse   190 AQMPASALQDG-CKDISTQLISNMDID----VILGGGRKFMFPKGTPDQEYPTDTKQAGTRLDGR 249

  Fly   264 NLIEEWQQTKPGNARVVFSRTDLLNNDA-QNTDFLLGLFNASHLAY--HMDDSIDTPTLPEMTAA 325
            ||::||.....| ||.|::|::|:.... ::...|:|||..:.:.|  |.|.:.| |:|.|||..
Mouse   250 NLVQEWLAKHQG-ARYVWNRSELIQASLNRSVTHLMGLFEPNDMKYEIHRDPAQD-PSLAEMTEV 312

  Fly   326 AINVLSRDPNGYFLFVEGGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHG 390
            |:.:|||:|.|::||||||||||.||||.|.:||.|.|.|..||.||.:||:..||:|:|:|||.
Mouse   313 AVRMLSRNPKGFYLFVEGGRIDHGHHETVAYRALTEAVMFDSAVDKADKLTSEQDTMILVTADHS 377

  Fly   391 HTVTISGYPDVNNSIVGLNSELSNVDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKP 455
            |..:..||.....||.|| :.....|...:|||.|.|||.    ||..:|.  |.|:...:.|.|
Mouse   378 HVFSFGGYTQRGASIFGL-APFKAEDGKSFTSILYGNGPG----YKLHNGA--RADVTEEESSNP 435

  Fly   456 DAIYPHGVPMTEETHGGGDVAVYAHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYC 520
            .......||::.|||.|.|||::|       :||.:||..||.||:.:.|:|.||:||.| .|.|
Mouse   436 TYQQQAAVPLSSETHSGEDVAIFA-------RGPQAHLVHGVQEQNYIAHVMAFAACLEP-YTDC 492

  Fly   521 DLQPKARYS 529
            .|...|..|
Mouse   493 GLASPAGQS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	193/457 (42%)
Alppl2	NP_031459.3	Alk_phosphatase	51..486	CDD:333956	193/457 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750