DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp1 and Akp3

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	504	Identity:	215/504 - (42%)
Similarity:	281/504 - (55%)	Gaps:	42/504 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRL 100
            |.::..||...|...|.......|.|..|||:|.||||||.||||||.||..|||.|.:|....|
Mouse    24 EEENPAFWNKKAAEALDAAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETPL 88

  Fly   101 EFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSI 165
            ..::|.|:.|||||.|::||.|||.||:|||.|:|.||.||||:|....:.|..:.  .|.:.|:
Mouse    89 AMDRFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTF--GNEVFSV 151

  Fly   166 AAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDGDVG 230
            ...|.|..||.|:||||||.||||:|.|.||.||::..|.|:.......| |.|||.|||.   .
Mouse   152 MYRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNWYGDADMPASALREG-CKDIATQLIS---N 212

  Fly   231 KRLRVVMGGGTIKFL----------PNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTD 285
            ..:.|::|||. |::          ||..|:.    |.|||.|||::||.....| ::.|::|..
Mouse   213 MDINVILGGGR-KYMFPAGTPDPEYPNDANET----GTRLDGRNLVQEWLSKHQG-SQYVWNREQ 271

  Fly   286 LLNNDAQ--NTDFLLGLFNASHLAYHMD-DSIDTPTLPEMTAAAINVLSRDPNGYFLFVEGGRID 347
            |:.. ||  :..:|:|||......:.:. |.:..|:|.:||.||:.||||:|.|::|||||||||
Mouse   272 LIQK-AQDPSVTYLMGLFEPVDTKFDIQRDPLMDPSLKDMTEAAVKVLSRNPKGFYLFVEGGRID 335

  Fly   348 HAHHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSEL 412
            ..||...|..||.|.|.|..|:.:|.|||:..|||.:|:|||.|..:..||.....||.|| :.|
Mouse   336 RGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTADHSHVFSFGGYTLRGTSIFGL-APL 399

  Fly   413 SNVDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAV 477
            :.:|..|||||.|.|||.|.       |..||.::...:.|.........||:..|||||.|||:
Mouse   400 NALDGKPYTSILYGNGPGYV-------GTGERPNVTAAESSGSSYRQQAAVPVKSETHGGEDVAI 457

  Fly   478 YAHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKA 526
            :|       :||.:||..||.||:.:.|:|.||.||.| .|.|.|.|.|
Mouse   458 FA-------RGPQAHLLHGVQEQNYIAHVMAFAGCLEP-YTDCGLAPPA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	200/461 (43%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	200/461 (43%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.760