DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp1 and Alpp

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	208/499 - (41%)
Similarity:	278/499 - (55%)	Gaps:	31/499 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRL 100
            |.::..||...|...|.......|.|..|.|:|..:||||.|.||||.||..||.:|.:|....|
  Rat    23 EEENPAFWNRKAAEALEAAKKLQPIQTSANNLIILMGDGMGVSTVTATRILKGQQQGHLGPETPL 87

  Fly   101 EFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSI 165
            ..::|.::.|||||..:|||.|||.|.:|:|.|:|.|...||::|....|.|..:.  .|.:.|:
  Rat    88 AMDRFPHMALSKTYNTDKQVPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTW--GNEVVSV 150

  Fly   166 AAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDG-DV 229
            ...|.|..||.|:||||.|.||||||.||||.||::.||..::......| |.|||.|||.. |:
  Rat   151 MHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRNWYSDAHMSTAALQEG-CKDIAMQLISNTDI 214

  Fly   230 GKRLRVVMGGGTIKFLPNTTNDVF-----GNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLLNN 289
            .    |::|||.....|..|.|..     ...|.|||.|||::||.....| |:.|::||:|:..
  Rat   215 D----VILGGGRKFMFPKGTPDQEYPTDPQQAGTRLDGRNLVQEWLAKHQG-AQYVWNRTELIQA 274

  Fly   290 DA-QNTDFLLGLFNASHLAYHMD-DSIDTPTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHAHHE 352
            .. ::...|:|||..:.:.|::| |....|:|.|||..|:::|||:|.|::||||||||||.|||
  Rat   275 SLNRSVTHLMGLFEPNDMKYNIDRDPTQDPSLAEMTEVAVHMLSRNPKGFYLFVEGGRIDHGHHE 339

  Fly   353 TKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSNVDQ 417
            ..|.:||.|.|.|..||.||.:||:..||:|:|:|||.|..:..||.....||.|| :.....|.
  Rat   340 AIAYRALTEAVMFDSAVDKADKLTSEKDTMIIVTADHSHVFSFGGYTQREASIFGL-APFKAGDG 403

  Fly   418 LPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYAHVV 482
            ..:|||.|.|||.    ||..:|:  |.|:...:.|.|.......||::.|||.|.|||::|
  Rat   404 KSFTSILYGNGPG----YKLNNGI--RADVTEEESSNPTYQQQAAVPLSSETHSGEDVAIFA--- 459

  Fly   483 EYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKA 526
                :||.:||..||.||:.:.|:|.||.||.| .|.|.|.|.|
  Rat   460 ----RGPQAHLVHGVQEQNYIAHVMAFAGCLEP-YTDCGLAPPA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	193/456 (42%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	193/456 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351438
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.860