DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp1 and alp3

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001265768.1	Gene:	alp3 / 100330410	ZFINID:	ZDB-GENE-120919-1	Length:	534	Species:	Danio rerio

Alignment Length:	508	Identity:	216/508 - (42%)
Similarity:	299/508 - (58%)	Gaps:	39/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRL 100
            |.::.|||...||.||.:.||...|...|||::.||||||.|.|:||.||..|||:...||...:
Zfish    21 EEENPEFWRKSAQNTLRSALSRKINTNVAKNIVLFLGDGMGVTTITAARILKGQLQKHSGEETVM 85

  Fly   101 EFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSI 165
            ..:.|..|||:|.|.|:.|:.|||.||:|||.|:|.|..|:||:|......||..:  .|.::||
Zfish    86 NMDTFPNVGLAKVYSVDFQIPDSAATATAYLCGVKTNLNTVGVSAAARNGVCRSQK--GNEVTSI 148

  Fly   166 AAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQL---IDG 227
            ..||....||.|:||||||.||:||..:||:::|.:.||.|:.......| |.|||.||   ||.
Zfish   149 LRWAKDAGKSVGIVTTTRVQHATPAASFAHSASRTWYSDADLPASAATEG-CVDIATQLLHNIDI 212

  Fly   228 DVGKRLRVVMGGGTIKFL-------PNTTNDVFGNKGQRLDNRNLIEEWQQTKPGN-ARVVFSRT 284
            |      |::|||. |::       |...:|. ..:|||.|.||||::|.|.|.|. ||.|:::|
Zfish   213 D------VIIGGGR-KYMTPKGFPDPEYPSDA-SAQGQRRDGRNLIQDWIQMKEGKVARYVWNKT 269

  Fly   285 DLLNNDAQNTDFLLGLFNASHLAYHM--DDSIDTPTLPEMTAAAINVLSRDPNGYFLFVEGGRID 347
            |....|.:.||:|:.||..:.|.:.:  |.|:| |::.|.|..||.:|.::|.|:||.|||||||
Zfish   270 DFDAVDPEKTDYLMALFEPADLRFDVERDHSMD-PSISETTDKAIQILKKNPKGFFLLVEGGRID 333

  Fly   348 HAHHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSEL 412
            ..||.::|..||.|.|...:||.:..:||:..:||.:|:|||.|..|.:|||...|||:| .|.:
Zfish   334 QGHHSSRASAALHEAVALDEAVSRGLELTDEEETLTIVTADHSHAFTFNGYPFRGNSILG-KSPI 397

  Fly   413 SNVDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAV 477
            ...|.||||::.|.|||.    :|.|:.  :|.|:|.:|.:..|.|....||:..|||||.||||
Zfish   398 FASDFLPYTTLMYGNGPG----HKITNN--KRPDIRKVDTADKDYIQQSAVPLDSETHGGEDVAV 456

  Fly   478 YAHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKARYSP 530
            :|       :||.:|||.|||||:.:||.|.:|:|:|....:|.:..|...:|
Zfish   457 FA-------RGPMAHLFQGVYEQNYIPHAMAYAACIGENQQHCAITAKPDENP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	200/461 (43%)
alp3	NP_001265768.1	PhoA	30..482	CDD:224699	206/477 (43%)
alp3	NP_001265768.1	Alk_phosphatase	49..485	CDD:278666	200/461 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593224
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910