DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aef1 and hkb

DIOPT Version :9

Sequence 1:	NP_001262157.1	Gene:	Aef1 / 40370	FlyBaseID:	FBgn0005694	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster

Alignment Length:	275	Identity:	74/275 - (26%)
Similarity:	108/275 - (39%)	Gaps:	49/275 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKSLPHAHAAATAMSS-----NCDIVIVAAQPQTTIANNN---------NNETVTQATHPAHMAA 54
            :|..|.|....|.::|     :||....:|....:.::|:         |:.:.|:.:.|...||
  Fly    34 VKQEPEAITIKTELASSSFGHDCDGDFSSASSSASSSSNSSKSCYEEALNHSSYTRTSTPLLDAA 98

  Fly    55 VQQQQQQQQQQQQQHHQQQQQQSSGPPSVPPPPTELPLPFQMHLSGISAEAHSAAQAAAMAAAQA 119
            ........|......|      ::...|:.||....|.     ||..|...::||.|||.||:..
  Fly    99 PHPVFSHPQSSPLDTH------AAATASLAPPNQHAPF-----LSAASDLYYAAAAAAAAAASTP 152

  Fly   120 AAAQAAAAEQQQPPPPTSHLTHLTTHSPTTIHSEHYLANGHSEHPGEGNAAVGVGGAVREPEKPF 184
            .|......:     |.|..|............::....|...:.|                 |.|
  Fly   153 TAVPGFGMD-----PFTMGLMEQEYARVMAEDAQLKALNSRKQRP-----------------KKF 195

  Fly   185 HCTVCDRRFRQLSTLTNHVKIHTGEKPYKC--NVCDKTFRQSSTLTNHLKIHTGEKPYNCNFCPK 247
            .|..||..|.....|..|::|||||:|:||  |.|.|||.::..||.|.:||||.:||.|:.|.|
  Fly   196 KCPNCDVAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGK 260

  Fly   248 HFRQLSTLANHVKIH 262
            .|.:...|..|:|.|
  Fly   261 KFGRRDHLKKHMKTH 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aef1	NP_001262157.1	C2H2 Zn finger	186..206	CDD:275368	6/19 (32%)
		zf-H2C2_2	199..223	CDD:290200	15/25 (60%)
		C2H2 Zn finger	214..234	CDD:275368	9/21 (43%)
		zf-H2C2_2	227..251	CDD:290200	13/23 (57%)
		C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		zf-H2C2_2	255..279	CDD:290200	4/8 (50%)
		C2H2 Zn finger	270..290	CDD:275368
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	31/65 (48%)
		zf-C2H2	195..217	CDD:278523	7/21 (33%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		zf-H2C2_2	210..236	CDD:290200	15/25 (60%)
		C2H2 Zn finger	225..247	CDD:275368	9/21 (43%)
		zf-H2C2_2	239..264	CDD:290200	13/24 (54%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	54	1.000	Inparanoid score	I1809
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050